妊高征患者血浆中分子物质含量变化及其临床意义

目的:探讨中分子物质(MMS)在妊娠高血压综合征(妊高征)患者血浆中的变化及其临床意义。方法:采用改进的紫外吸收法测定82例妊高征患者、98例正常妊娠妇女及66例正常非妊娠妇女血浆MMS含量。结果:妊高征患者血浆MMS水平显著高于正常妊娠妇女及正常非妊娠妇女(P<0.01);在轻、中、重度妊高征之间,血浆MMS有显著差别(P<0.01或P<0.05),MMS水平越高,妊高征病情越重;妊高征患者分娩后48 h其血浆MMS水平有所回落(P<0.05)。正常妊娠妇女及正常非妊娠妇女血浆MMS水平没有显著性差异(P>0.05)。结论:MMS与妊高征发病学有关,MMS可作为判断妊高征病情程度的指标之一。

Changes and clinical significances of middle molecular substances levels in the plasma of patients with pregnancy induced hypertension

Objective:To study the changes and clinical significances of middle molecular substances levels in the plasma of patients with pregnancy induced hypertension(PIH).Methods:Plasma MMS concentrations in 82 cases of PIH,98 cases of normal pregnant women and 66 cases of healthy nonpregnant women were measured by an improved ultra-violet ray absorption method.Results:Plasma MMS concentrations were significantly higher in PIH group than those in normal pregnant women group and healthy nonpregnant women group respectively(P<0.01).There was significant difference among plasma MMS levels from patients with mild,moderate,and severe PIH(P<0.01 or P<0.05).The higher plasma MMS levels,the worsen state of PIH.The plasma MMS levels decreased significantly in 48h post partum in PIH group(P<0.05).There was no obvious difference between plasma MMS levels from normal pregnant women and healthy nonpregnant women(P>0.05).Conclusion:The changes of plasma MMS levels are believed to be association with pathogenesis of PIH and can be used as a biochemical marker for judging the progression of PIH.