MicroRNA-34b/c rs4938723 T>C多态性与中国汉族人群肾细胞癌易感性的相关性

目的研究中国汉族人群microRNA-34b/c启动子区TC(rs4938723)多态性与肾细胞癌易感性之间的关系。方法采用病例对照研究模式,通过TaqMan探针PCR法检测年龄和性别匹配的710例中国汉族人群肾细胞癌患者和760例正常人群的microRNA-34b/c启动子区TC(rs4938723)基因型,探讨该位点基因多态性与肾细胞癌易感性之间的关系。结果与TT/TC基因型携带者相比,CC型(OR=1.53,95%CI=1.06~2.21,CC基因型比TT基因型;OR=1.48,95%CI=1.05~2.10,CC基因型比TT/TC基因型)携带者发生肾细胞癌的危险性明显升高。分层分析显示携带CC基因型的老年患者(OR=1.80,95%CI=1.08~3.01)、男性患者(OR=1.64,95%CI=1.08~2.51)、吸烟患者(OR=2.07,95%CI=1.16~3.69)及饮酒患者(OR=1.94,95%CI=1.01~3.73)发生肾细胞癌的危险性明显升高。结论 microRNA-34b/c启动子区TC(rs4938723)基因多态性与我国汉族人群肾细胞癌易感性有关,CC型携带者发生肾细胞癌的危险性要明显高于TT/TC型携带者。

MicroRNA-34b/c rs4938723 T>C polymorphism is associated with renal cell carci-noma risk in southern Han ethnic Chinese population

Objective To evaluate the relationship between the microRNA‐34b/c promoter region T〉C （rs4938723） pol‐ymorphism and renal cell carcinoma risk （RCC ） in southern Han ethnic Chinese population .Methods The rs4938723 was genotyped using TaqMan method to explore the relationship between this polymorphism and the risk of RCC in a case‐control study of 710 RCC patients and 760 control subjects .Results Individuals carrying the CC genotype had a significantly in‐creased RCC risk odds ratio （OR）=1 .53 ,95% confidence interval （CI）=1 .06~2 .21 for CC vs .TT ,and OR=1 .48 ,95%CI=1 .05~2 .10 for CC vs .TT/TC ,respectively] compared with those with TT or TT/TC genotypes .Furthermore ,the in‐creased risk was more evident in the subgroups of older subjects （OR=1 .80 ,95% CI=1 .08~3 .01） ,males （OR=1 .64 ,95%CI=1 .08~2 .51） ,smokers （OR=2 .07 ,95% CI=1 .16~3 .69） and drinkers （OR=1 .94 ,95% CI=1 .01~3 .73） .Conclu‐sion These results suggest that the microRNA‐34b/c rs4938723 C allele may increase the susceptibility to RCC by decreasing the activity of microRNA‐34b/c promoter compared with T allele .