出血性中风中经络血清sICAM-1、MDA变化的临床研究

探讨急性脑出血中医各证型血清可溶性细胞间粘附分子（sICAM-1）和丙二醛（MDA）含量变化及意义.采用双抗体夹心酶联免疫吸附（ELISA）法、硫代巴比妥酸（TBA）法分别测定64例急性脑出血患者和20例健康人血清中sICAM-1、MDA的含量.结果：急性脑出血患者血清sICAM-1、MDA含量明显升高,以痰热腑实组升高最为显著.结论：急性脑出血白细胞粘附、机体氧化应激增强,患者血清sICAM-1、MDA明显升高,二者关系密切,参与了脑出血后脑损伤的病理过程,以痰热腑实证为最明显.

Clinical Study of Change on Serum sICAM-1 and MDA in Patients with TCM Syndrome Types of Apoplexy Involving Channels and Collaterals with Acute Intracerebral Hemorrhage

To explore the changes and their significance of serum soluble intercellular adhesion molecule-1(sICAM-1) and malondialdehyde(MDA) contents in patients with acute intracerebral hemorrhage(AICH) of different TCM syndrome.Serum sICAM-1 and MDA contents were determined respectively by double antibody sandwich enzyme-linked immunosorbent assay(ELISA) and thiobarbituric acid(TBA) in 64 cases of AICH and 20 healthy people.Results: Serum sICAM-1 and MDA contents increased significantly in patients with AICH.Among the various groups of involving channels and collaterals,the two indexes of phlegm-heat and fu-organ excess group increased most obviously.Conclusion: Strengthening of leukocyte adherence and oxidative stress in patients with AICH are closely related to the increases of serum sICAM-1 and MDA,which participate the pathological course of cerebral injury after cerebral hemorrhage.It is the most remarkable in phlegm-heat and fu-organ excess group.