| Effects of Cyclosporin A on Proliferation of Cultured Rat Mesangial Cells |
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| 作者姓名： | 孙建平 王韵琴 |
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| 作者单位： | Department of Pediatrics，Tongji Hospoital，Tongji Medical University，Whhan 430030 |
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| 摘 要： | Mesangialproliferativeglomeru-lonephritis(MsPGN)isacommonpatho-logicaltypeofglomerulardiseasesinchil-drenl].Itischaracterizedbyincreasednumbersofmesangialcells(MC)andin-creasedmesangialmatrix,finallyresultinginglomerulosclerosis.ProliferationofmesangialcellsareofgreatimportanceinpathologicalchangesandprognosisofgIomerulardiseases.Thus,attentionispaidtosearchofaninhibitorofproliferationofMCandinvestigationofitsmechanism.Cy-closporinA(CsA)isanimmunosuppressiveagentusedinthetreatmentofglome…
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| 关 键 词： | cyclosporin A mesangial cells tumor necrosis factor-α |
| 收稿时间： | 1 December 1995 |
Effects of cyclosporin a on proliferation of cultured rat mesangial cells |
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| Sun Jumping,Wang Yunqin.Effects of Cyclosporin A on Proliferation of Cultured Rat Mesangial Cells[J].Journal of Zuazhong University of Science and Technology: Medical Edition,1997,17(2):115-117. |
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| Authors: | Sun Jumping Wang Yunqin |
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| Institution: | (1) Department of Pediatrics, Tongji Hospital, Tongji Medical University, 430030 Wuhan |
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| Abstract: | Summary The proliferation of mesangial cells on cyclosporin (CsA) test medium was studied by MTT assay and TNF-α in cultured supernatant
was examined by using ELISA. The results showed that cyclosporin A significantly inhibited the proliferation of mesangial
cells at the concentration between 0. 25 – 15 μg/ml (IC50 1 μg/ml). This action appeared to be dose-dependent. Release of
TNF-α from mesangial cells stimulated by LPS was also dose-dependently suppressed. It is suggested that cyclosporin A play
an important role in antiprohferation mechanism of mesangial cellsin vitro. |
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| Keywords: | cyclosporin A mesangial cells tumor necrosis factor-α |
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