Promoters P3, Pa/Pb,P4, and P5 upstream from bla(TEM) genes and their relationship to beta-lactam resistance |
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| Authors: | Lartigue Marie Frédérique Leflon-Guibout Véronique Poirel Laurent Nordmann Patrice Nicolas-Chanoine Marie-Hélène |
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| Affiliation: | Service de Microbiologie-Hygiène, H?pital Ambroise Paré Assistance Publique-H?pitaux de Paris, Boulogne, France. marie-helene.nicolas-chanoine@apr.ap-hop-paris.fr |
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| Abstract: | Using an isogenic system, we have determined the impact that the four promoters known to control bla(TEM) gene expression have on beta-lactamase activity. For both TEM-1 and TEM-30, this activity gradually increased in relation to the presence of promoters P3, Pa/Pb, and P4 upstream of the corresponding gene. Promoter P5, only found upstream of the bla(TEM-1B) gene, was related to the highest expression of this gene. |
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