中年糖耐量减低患者肱动脉血管舒张功能与身体成分和糖代谢的关系

目的探讨中年糖耐量减低患者血管内皮功能与身体成分和糖代谢的关系。方法采用PhilipsIU-22型彩色多普勒超声诊断系统探测肱动脉血管舒张功能、身体成分和糖代谢指标,并进行统计学分析。结果(1)糖耐量减低组冠心病的患病率、糖尿病家族史和心血管疾病家族史的阳性率较糖耐量正常组明显增高。(2)糖耐量减低组的体质指数、体脂百分数、腰围和口服葡萄糖耐量试验2h血糖与糖耐量正常组对比具有非常显著性差异,而腰臀比、空腹血糖亦明显高于糖耐量正常组,但两组之间收缩压和舒张压没有明显的差别。(3)糖耐量正常和减低两组的肱动脉内皮依赖性舒张百分数的差异具有显著性意义(P<0.05),而肱动脉基础内径、非内皮依赖性舒张百分数的差异无显著性统计学意义。(4)中年糖耐量减低患者肱动脉内皮依赖性舒张百分数与口服葡萄糖耐量试验后2h血糖浓度相关(r=0.269,P<0.05)。(5)多元逐步回归分析发现,口服葡萄糖耐量试验2h血糖浓度是中年糖耐量减低患者肱动脉内皮依赖性舒张功能的预测变量,其方程式为Y△Dia-P%=0.981×OGTT2h血糖浓度 7.608。结论中年糖耐量减低患者存在肱动脉血管舒张功能障碍、身体成分和糖代谢指标发生改变,而且胰岛素抵抗、口服葡萄糖耐量试验2h血糖的异常在中年糖耐量减低患者肱动脉舒张功能障碍中起重要的作用。

The Relationship between the Brachial Arterial Vasodilation Function,Body Composition and Glucose Metabolism in Middleaged Patients with Impaired Glucose Tolerance

Aim Discuss the relation between vascular endothelium function,body composition and glucose metabolism in middleaged patients with impaired glucose tolerance.Methods Adopt the Philips IU-22 color Doppler ultrasound diagnostic system to detect vascular endothelium function,body composition and glucose metabolism indexes,and process a statistic analysis.Result(1) The rate of impaired glucose tolerance group to catch coronary heart disease,the positive rate of diabetes family history and family history in cardiovascular disease,are all obviously higher than the normal glucose tolerance group.(2)Compared to the normal glucose tolerance group,the BMI,BF%,waist circumference and 2-hour postprandial blood glucose of the impaired glucose tolerance group show significant difference,while the WHR and Fasting blood glucose are obviously higher.There is no significant difference in the SBP and DBP between two groups.(3)There is significant difference in the brachial arterial Dia-P% between two groups,while the brachial arterial internal diameter and Dia-N% show no significant difference.(4)The Dia-P% of middleaged impaired glucose tolerance patients is related the OGTT2h blood glucose.(5) The multivariate successive regression equation of Dia-P% in the middleaged impaired glucose tolerance patients show a predictor variable:OGTT2h blood glucose.Conclusion Brachial arterial vasodilation dysfunction exists in the middleaged impaired glucose tolerance patients,and the indexes of body composition and glucose metabolism change.Meanwhile,the abnormality of insulin resistance and OGTT2h blood glucose play an important role in the brachial arterial vasodilation dysfunction of middleaged IGT patients.