基于生物学指标的糖尿病肾病血瘀证研究

目的:探索糖尿病肾病血瘀证与微观指标之间的关系,为糖尿病肾病血瘀证提供客观化依据。方法:多中心收集糖尿病肾病182例,辨证为血瘀证104例,非血瘀证78例,以30例健康人为正常对照,检测ET、NO、t-PA、PAI-1、HbA1c、血脂及血液流变学指标,用统计学方法分析上述指标与各组之间的关系。结果:(1)与正常组比较,糖尿病肾病组所有上述观察指标差异均有统计学意义(P<0.05,P<0.01);(2)与非血瘀证组比较,血瘀证组ET、NO、t-PA、PAI-1、HbA1c、TG、HDL、LDL、Fib、PV、TK及LSR差异有统计学意义(P<0.05,P<0.01);TC、HSR差异无统计学意义(P>0.05)。结论:糖尿病肾病血瘀证患者存在血糖、血脂、血液流变学、纤溶及血管内皮系统异常,可为糖尿病肾病血瘀证客观化提供依据。

Study of Blood Stasis Syndrome in Diabetic Nephropathy Based on Microscopic Indexes

To explore the relationship between the levels of microscopic indexes and the syndrome of blood stasis in the patients with Diabetic Nephropathy（DN） and to provide objective evidence for it. Methods：IS2 patients multicenrtic with DN were divided into two groups： syndrome of blood stasis（group of A,n = 104） ,and syndrome of non - blood stasis （group of B,n = 78）. the normal （ group of C, n = 30） were took as the control. The indexes in serum or plasma were detected, which were nitric oxide （NO） .endothelin（ET） .tissue type plasminogen activator （ t - PA） .human plasminogen activator inhibitor 1 （PAI - 1 ） ,HbAlc.Tri glyceride （ TG）. total cholesterol （ TC ）. low density lipoprotein （ LDL）, high density lipoproteins （ HDL ）. fibrinogen （ Fib ）. plasma vis- cosity （PV） .lower shear rate （ LSR ）, higher shear rate （HSR） and erythrocyte metamorphosis index （ TK ）, the relationship between the syndromes and the levels of microscopic indexes were analyzed by the statistical method. Results： （ 1 ） There was statistical significance in all the indexes above between group of C and group of DN （ P 〈 0. 05, P 〈 0.01 ） ; （2） There was statistical significance in indexes of ET. NO. t - PA. PAI- 1. HbA 1 c. TG. HDL, LDL. Fib. PV, TK and LSR between group of A and group of B （ P 〈 0. 05, P 〈 O. O1 ）, while there was not statistical significance in TC. I-ISR between them （ P 〉 0.05 ）. Conclusion： Abnormality developed in blood glu- cose.blood lipid.hemorhoology.vasoactive factor and also in fibrinolytic activity of patients with syndrome of blood stasis in DN.