| 羧甲基壳聚糖—锌络合物的制备及对大鼠血清SOD活性的影响 |
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| 引用本文： | 曹朝晖,李邦良,胡小波.羧甲基壳聚糖—锌络合物的制备及对大鼠血清SOD活性的影响[J].微量元素与健康研究,2011,28(4):4-6. |
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| 作者姓名： | 曹朝晖 李邦良 胡小波 |
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| 作者单位： | 南华大学生化与分子生物学教研室,湖南,衡阳,421001 |
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| 基金项目： | 湖南省衡阳市科技局资助项目(2009ks33) |
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| 摘 要： | 目的:研究羧甲基壳聚糖与锌(Ⅱ)络合物的制备并初步探讨其对抗氧化酶SOD活性的影响。方法:用水溶性的羧甲基壳聚糖与锌(Ⅱ)制备络合物,用红外、紫外光谱等初步分析络合物的理化性质,并研究该络合物对饲高糖高脂大鼠血清SOD活性的影响。结果:紫外、红外光谱表明锌可与羧甲基壳聚糖发生络合反应;羧甲基壳聚糖—锌能显著提高饲高糖高脂大鼠SOD活性(P<0.05)。结论:羧甲基壳聚糖可与锌(Ⅱ)形成络合物,并能增强SOD活性。
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| 关 键 词： | 羧甲基壳聚糖-锌(Ⅱ) 制备 SOD |
Preparation of carboxymethyl Chitosan complexe with Zinc(II)and study on its effect on serum SOD activity in rats |
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| CAO Zhao-hui,LI Bang-liang,HU Xiao-bo.Preparation of carboxymethyl Chitosan complexe with Zinc(II)and study on its effect on serum SOD activity in rats[J].Studies of Trace Elements and Health,2011,28(4):4-6. |
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| Authors: | CAO Zhao-hui LI Bang-liang HU Xiao-bo |
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| Institution: | CAO Zhao-hui,LI Bang-liang,HU Xiao-bo(The Department of Biochemistry and Molecular Biology,University of South China,Hengyang 421001,China) |
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| Abstract: | Objective: To prepare Zinc(Ⅱ)-carboxymethyl Chitosan complex and study its effect on serum SOD in high fat/high sucrose-fed Wistar rats..Methods: The coordination compounds of carboxymethyl Chitosan with Zinc(Ⅱ) were synthesized and studied by TJ-IR and UV-V.Its effects on serum SOD in the diabetic rats were investigated.Results :TJ-IR and UV-V indicated Zinc element and carboxymethyl Chitosan could form a complex.The complex might improve SOD activity in high fat/high sucrose-fed Wistar rats(P<0.05).Conclusion: carboxymethyl Chitosan could form the cooperation thing with Zinc(II).The complex might increase SOD activity. |
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| Keywords: | carboxymethyl Chitosan-Zinc(Ⅱ) preparation SOD |
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