Response of Cats to Inhaled Mixtures of SO2 and SO2-NaCl Aerosol in Air |
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| Authors: | Morton Corn PhD Nancy Kotsko Dolores Stanton William Bell Armand P. Thomas MS |
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| Affiliation: | 1. Department of Occupational Health , Graduate School of Public Health, University of Pittsburgh , Pittsburgh;2. Department of Occupational Health , Graduate School of Public Health, University of Pittsburgh , Pittsburgh;3. Mobil Oil Corporation , Philadelphia |
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| Abstract: | Twenty healthy, adult male cats were lightly anesthetized with pentobarbital (Nembutal) sodium and tracheotomized; respiration was maintained by pump, Medical-grade breathing air, with or without sulfur dioxide alone or in combination with sodium chloride aerosol was delivered in predetermined exposure sequencer Pulmonary flow resistance and lung compliance were evaluated. Pollutants were also delivered via endotracheal catheter or face mask, or both. Approximately 20 ppm of SO2 in air was required to evoke a significant change in pulmonary flow resistance in “reactors.” The majority of animals showed no response to this concentration of SO2 either alone or with NaCl aerosol (10 mg/cu m). An increased frequency of significant changes in pulmonary flow resistance was suggested when pollutants were delivered via endotracheal catheter or face mask. All alterations in parameters of response were reversible shortly after exposure ceased. |
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