Cerebral Cortical Metabolism After Chronic Exposure to Ozone |
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| Authors: | Eberhard G. Trams PhD Carl J. Lauter Elise A. Brandenburger Brown PhD Oscar Young |
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| Affiliation: | 1. Laboratory of Neurochemistry, National Institute of Neurological Diseases and Stroke, National Institutes of Health , 20014, Bldg 10, Room 3D-04, Bethesda , Md;2. Laboratory of Chemical Pharmacology, National Heart and Lung Institute, National Institutes of Health , Bethesda , Md |
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| Abstract: | This study represents a biochemical survey of cerebral cortex in dogs, in which an increased latency of evoked electroencephalogram EEG potentials of visual cortex had been observed after prolonged exposure to ozone. Portions of occipital and parietal cortex were analyzed from 44 dogs which had been exposed to 1 to 3 ppm O3 for 18 months. Contents of norepinephrine and epinephrine, lipid hydroperoxides, K+, Na+, and Cl- were measured. In addition, the activity of the following enzymes was determined: monoamine oxidase, catechol-O-methyltransferase, cholînesterase, 5’-nu-cleotidase, and Na+, K+, and Mg++ adenosine triphosphatases (ATP’ases). Catechol-O-methyltransferase activity showed a steady decline as the daily exposure to 1 ppm O3 was increased from 8 to 24 hours. Concurrently, the catecholamine content of the tissues declined. |
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| Keywords: | air pollution gender differences HRQoL population study traffic noise vehicle traffic density |
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