通络益气法治疗急性脑梗塞临床研究

目的 :旨在观察通络益气法治疗急性脑梗塞的临床疗效 ,并初步探讨其作用机制。方法 :本文选择急性脑梗塞患者 6 2例 ,随机分为通络益气组和活血化瘀组 ,治疗前后分别测定患者血浆内皮素 (ET)、一氧化氮 (NO)及血液流变学指标 ,并与正常健康人群作对照研究。结果 :急性脑梗塞发作时 ,患者血浆ET、NO水平明显升高 (P <0 .0 1) ,治疗后ET下降 ,NO升高 ,ET/NO下降 ,而通络益气组的下降程度明显高于活血化瘀组 (P <0 .0 1) ,同时患者全血粘度、血浆粘度及血小板聚集率等均较治疗前下降 (P <0 .0 1)。结论 :通络益气法治疗急性脑梗塞的主要作用机制在于改善血管内皮功能 ,抑制ET的生成 ,解除血管痉挛 ,降低血粘度 ,增加脑血流量 ,保护缺血性脑组织的损伤。

Taditional Chinese Medical Study for the Methods of Freeing Network Vessels and Boosting Qi in Acute Cerebral Infarction

Objective: To observe the clinical effect and investigate the mechanism of the method of freeing network vessels and boosting Qi(FNVBQ)on acute cerebral infarction. Methods: 62 patients of acute cerebral infarction were randomly divided into two groups: the FNVBQ group and the activating blood and removing stasis(ABRS)group. The levels of serum endothelin(ET),nitric oxide (NO) and the parameter of hemorrheology were measured before and after treatment. Results: The levels of serum ET and NO obviously elevated in acute cerebral infarction( P< 0.01).After treatment,the levels of serum ET decreased,NO increased,and the rate of ET/NO decreased,while the decreasing rate of the FNVBQ group was more remarkable,compared with the ABRS group ( P< 0.01).Meantime,the viscosity of whole blood and plasma,and the platelet aggregation rate decreased significantly,compared with those before treatment( P< 0.01). Conclusion: FNVBQ could improve the vascular endothelium function,inhibit the vasoconstriction,promote to rebuild and open the collateral vessels and increase cerebral blood flow. Therefore,FNVBQ might prevent cerebrovascular damage.