中药逆转肿瘤细胞多药耐药研究进展

阐述了肿瘤多药耐药（MDR）是临床化疗失败的主要原因之一，己成为恶性肿瘤化疗过程急需解决的问题。中药有毒性小、安全有效、多靶点等优势，在逆转肿瘤MDR的研究中正受到越来越广泛的关注。中药通过作用于介导MDR形成的膜转运系统、药物代谢系统、促进肿瘤细胞凋亡等机制，对多种肿瘤的MDR具有逆转作用。如何有效地从浩淼庞大的中药资源库中快速筛选并定位到具有逆转MDR活性的分子仍是目前中药研发亟待解决的瓶颈问题之一。建立科学合理的抗肿瘤药物筛选模型和高效可靠的方法和系统，能够满足现代医学的科学阐述要求，又能兼顾中医药本身的整体观念和辨证论治的思想，还需要大量艰苦的科学工作。

Advances and Prospect in Reversing Multidrug Resistance of Tumor Cells by Chinese Materia Medica

The development of multidrug resistance (MDR) to conventional therapy is one of the most important obstacles that lead to the failure of clinical chemotherapy in treating cancers and has become an extremely urgent one to overcome. Chinese materia medica which is capable of circumventing MDR with minimal adverse side effects, curative effects and multiple targets is an attractive resource library and has aroused more and more concern. Chinese materia medica has the activity to reverse the MDR of wide variety of tumors through mediatation in drug delivery system, drug metabolic system and promotion of apoptosis.