| 木防己碱对中枢神经系统影响的实验观察 |
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| 引用本文： | 吴向群,袁惠南. 木防己碱对中枢神经系统影响的实验观察[J]. 中国药理学通报, 1986, 0(1) |
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| 作者姓名： | 吴向群 袁惠南 |
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| 作者单位： | 卫生部药品生物制品检定所药理室，卫生部药品生物制品检定所药理室 现在浙西省药品检验所 |
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| 摘 要： | 本文观察到Tr具有抑制小鼠的自主活动,加强戊巴比妥钠及水合氯醛对中枢的抑制作用,拮抗咖啡因与苯丙胺的兴奋作用,推迟出现戊四氮和士的宁惊厥的潜伏期,延长士的宁致小鼠惊厥后死亡的时间,本品尚有镇痛和降温作用,表明Tr具有镇静、镇痛、降温等中枢抑制作用。
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| 关 键 词： | 盐酸木防己碱 镇静 镇痛 降温作用 |
Experimenintal Observation of the Effects of Trilobine on the Central Nervous System |
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| Wu Xiangqun. Experimenintal Observation of the Effects of Trilobine on the Central Nervous System[J]. Chinese Pharmacological Bulletin, 1986, 0(1) |
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| Authors: | Wu Xiangqun |
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| Affiliation: | Wu Xiangqun |
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| Abstract: | It has been observed that trilobine can inhibit automatic action of mice, strengthen inhibition by sodium pentobarbital or chloral hydrate on the central nervous system, antagonize excitation by caffeine and amphetamine, delay the incubation period of eclampsia by pentylenetetrazol and strychnine,and prolong the survival time of the mice convulsed by strychnine. Moreover, trilobine is possessed of analgesia and hypothermia, showing its inhibition on the central nervous system |
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| Keywords: | Trilobine hydrochloride Sedation Analgesia Hypo-thermia |
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