<Emphasis Type="Italic">S</Emphasis>-adenosylmethionine and <Emphasis Type="Italic">S</Emphasis>-adenosylhomocysteine levels in the aging brain of APP/PS1 Alzheimer mice |
| |
| Authors: | Carlijn R Hooijmans Henk J Blom Dinny Oppenraaij-Emmerzaal Merel Ritskes-Hoitinga Amanda J Kiliaan |
| |
| Institution: | (1) Department of Anatomy and Department of Cognitive Neuroscience, Donders Centre for Neuroscience, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands;(2) Laboratory of Pediatrics and Neurology, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands;(3) Central Animal Laboratory, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands; |
| |
| Abstract: | Hyperhomocysteinemia and factors of homocysteine metabolism, S-adenosylhomocysteine (AdoHcy) and S-adenosylmethionine (AdoMet), may play a role in Alzheimer’s disease (AD). With liquid-chromatography-tandem-mass-spectrometry
AdoMet and AdoHcy were determined in brains of 8- and 15-month-old APP/PS1 Alzheimer mice, and their possible roles in AD
brains investigated. The finding that AdoMet levels do not differ between the genotypes in (young) 8-month-old mice, but are
different in (older) 15-month-old APP/PS1 mice compared to their wild-type littermates, suggests that alterations in AdoMet
are a consequence of AD pathology rather than a cause. During aging, AdoMet levels decreased in the brains of wild-type mice,
whereas AdoHcy levels diminished in both wild type and APP/PS1 mice. The finding that AdoMet levels in APP/PS1 mice are not
decreased during aging (in contrast to wild-type mice), is probably related to less demand due to neurodegeneration. No effect
of the omega-3 fatty acid docosahexaenoic acid (DHA) or cholesterol-enriched diets on AdoMet or AdoHcy levels were found. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
