高尿酸血症与视网膜血管病变的相关性探讨

目的探讨高尿酸血症患者尿酸水平与视网膜动脉硬化的关系。方法选择济南市第二人民医院健康查体者中高尿酸血症145例,同期健康查体者中血尿酸正常者150例为对照组,观察视网膜动脉硬化程度,并采用颈动脉多普勒超声检测颈动脉硬化程度。结果高尿酸血症组视网膜动脉硬化及患病率明显高于对照组(P<0.05),血尿酸与视网膜动脉硬化程度呈正相关(r=0.893,P<0.05)。各级视网膜动脉硬化与同级颈动脉硬化之间血尿酸值无明显差异。结论高尿酸血症导致的大血管硬化程度与视网膜动脉硬化程度高度一致。眼底检查作为简便易行的全身动脉硬化检查方法,可早期对血尿酸进行干预,以预防心脑血管事件的发生。

Investigation of Relationship between Serum Uric Acid Level and Retinal Atherosclerosis

Objective To investigate the relationship between serum uric acid level and retinal atherosclerosis.Methods During the physical examination,295 cases were selected and divided into two groups: normal serum uric acid(n=150) and hyperuricemia(n=145).The oculal fundus were examined in all subjects undergoing carotid Doppler ultrasonography to measure the intimamedia thickness(IMT) of carotid artery and the extent of plaque formation.Results The incidence of retinal atherosclerosis in hyperuricemia group was hi...