女性生殖障碍相关疾病的发病机制及诊治研究进展

人类生殖健康是种族繁衍、民族兴旺和可持续发展的重要基石,涉及受精、胚胎着床、胚胎发育和生长等重要过程,任一环节发生问题,即导致生殖障碍.复发性流产是临床上严重影响女性生殖健康的不育症之一,占妊娠总数的1％～5％.课题组深入研究复发性流产的发病机制,在临床诊治方面积累了丰富经验,处于国内一流、国际领先水平.“免疫型复发性流产发病机制、诊断和治疗研究”项目获2008年国家科技进步二等奖和2011年国家人口与计划生育优秀成果一等奖.同时,随着我国社会经济的发展和人民生活水平的提高,疾病谱结构逐渐调整,目前,妇科恶性肿瘤的发病率有所上升且呈现年轻化趋势,妇科肿瘤已成为严重影响女性生殖健康的一大祸患.近年来,课题组在上皮性卵巢肿瘤的发病机制及靶向治疗方面的研究取得重大进展,近4年发表SCI论文10余篇,申报专利2项,“上皮性卵巢癌的转移及其耐药机制的靶向治疗”研究获2009年教育部科技进步二等奖、上海市科技进步三等奖和上海医学科技二等奖.

Research on the pathogenesis,diagnosis and treatment of female reproductive disorders

Human reproduction health is the basis of race expand and nation’s prosperity,which involves fertilization,embryo implantation,fetal development and growth.Any relevant problems could result in reproductive disorders.Recurrent spontaneous abortion(RSA),1%-5% incidence in pregnancy,is one of the most difficult infertility,which influences the female productive ability seriously.We major in the pathogenesis of RSA,and gained abundant experience in the diagnosis and treatment,which reached first class level at home and abroad.We are have gained National Scientific and Technological Progress second prize in 2008 and the National Population and Family Planning Outstanding Achievements first prize in 2011.Meanwhile,morbidity has changed with the development of social economy and improvement in living standard.Gynaecology oncology becomes more common and the age incidence is getting so lower that birth ability could be damaged.In recent years our research has concentrated on the pathogenesis and target treatment for epithelial ovarian tumor.Related findings have been published in the international journals,which bring us Ministry of Education Science and Technology Progress second prize,Shanghai Municipal Science and Technology Progress third prize,and Shanghai Medical Association Science and Technology Progress second prize in 2009.Also,we have applied for the patents based on the techniques developed during our research.