消化系统疾病的研究进展

上海交通大学医学院附属仁济医院消化学科在“211”二期项目建设成果的基础上,经过5年三期建设的努力,除在原有优势项目如对消化系肿瘤发生与诊治和慢性肝病诊治的研究取得了诸多成效外,还开辟了小肠疾病诊治研究的新领域.建设期间,系统研究了消化系肿瘤(胃癌和大肠癌)发生的分子机制、早期诊断和综合预防,特别是表观遗传修饰(DNA甲基化、组蛋白修饰、micro RNA等)与信号通路在消化系肿瘤发生和发展中的作用;建立胶囊内镜和双气囊内镜在小肠疾病诊断中的关键技术,从而提高小肠疾病的诊断率,探索并开拓了小肠内镜诊断应用的新途径,使小肠内镜在我国得到普及和推广,并对血管发育不良所致不明原因消化道出血进行临床创新性治疗及其机制探索;建立了慢性乙型病毒性肝炎肝纤维化非创诊断模型,同时系统阐述并证实了核苷类抗病毒药及氧化苦参碱等在抑制纤维化及减缓疾病进展中的作用和机制.以上研究成果获得两项国家科技进步二等奖,并进入“国家临床重点专科(消化内科)”和“国家临床重点专科(卫生部重点实验室)”建设行列,学科总体水平得以显著提高.

Advances in research of digestive diseases

On the basis of the achievements in the second phase of 211 project,the Department of Gastroenterology,Renji Hospital,Shanghai Jiaotong University School of Medicine has made lots of progresses in the original priority projects such as the generation,development,early diagnosis of gastrointestinal tumors,the diagnosis and treatment of chronic liver disease.In addition,we also open up new areas in terms of the diagnosis and treatment of intestinal diseases during the third phase construction.We studied systemically the molecular mechanisms,early diagnosis and prevention of gastric cancer and colorectal cancer,especially the role of epigenetic modifications(DNA methylation,histone modification and micro RNA,etc) and signaling pathways in the development of gastrointestinal tumors.To improve the diagnostic rate,we established the key technology of capsule endoscopy and double balloon endoscopy in the diagnosis of small bowel diseases,which popularized and promoted the application of the small intestine endoscopy in our country.In addition,we explored the innovative clinical therapy and its mechanism in the refractory gastrointestinal from vascular malformation.Moreover,we established non-invasive diagnosis model to predict liver fibrosis in chronic hepatitis B,and clarified the role and the mechanism of the nucleoside antivirals and oxymatrine in the inhibition of fibrosis and prevention its progress.Through the 5-year efforts,we have got two National Science and Technology Progress Awards,and have become the key national clinical specialist(Department of Gastroenterology) and the key national clinical specialist(Key Laboratory of Ministry of Health).The overall level of our discipline has been markedly improved.