| 三七花总皂苷对内皮素诱导的人主动脉血管平滑肌细胞c-myc、c-fos表达的影响 |
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| 引用本文： | 苑素云,王佑华,曹敏,周莉,周端.三七花总皂苷对内皮素诱导的人主动脉血管平滑肌细胞c-myc、c-fos表达的影响[J].上海中医药大学学报,2012(3):95-97. |
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| 作者姓名： | 苑素云 王佑华 曹敏 周莉 周端 |
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| 作者单位： | 上海中医药大学附属龙华医院ICU;上海中医药大学 |
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| 基金项目： | 上海市经委高新技术产业项目(沪创新J-58) |
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| 摘 要： | 目的:观察三七花总皂苷(PNFS)对内皮素(ET-1)诱导的人主动脉血管平滑肌细胞(HASMC)癌基因c-myc、c-fos表达的影响。方法:采用ET-1诱导HASMC异常增殖,应用RT-PCR方法检测PNFS对c-myc、c-fos mRNA表达的影响。结果:PNFS能明显抑制HASMC原癌基因c-myc mRNA表达(P<0.05),而对c-fos mRNA表达影响不明显。结论:PNFS可影响癌基因c-myc mRNA表达以抑制HASMC异常增殖。
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| 关 键 词： | 三七花总皂苷 人主动脉血管平滑肌细胞 c-myc c-fos |
Influence of Panax Notoginseng Flower Saponins on c-myc and c-fos Expressions in ET-1-induced Human Aortic Vascular Smooth Muscle Cells |
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| YUAN Su-yun,WANG You-hua,CAO Min,ZHOU Li,ZHOU Duan.Influence of Panax Notoginseng Flower Saponins on c-myc and c-fos Expressions in ET-1-induced Human Aortic Vascular Smooth Muscle Cells[J].Acta Universitatis Traditionis Medicalis Sinensis Pharmacologiaeque Shanghai,2012(3):95-97. |
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| Authors: | YUAN Su-yun WANG You-hua CAO Min ZHOU Li ZHOU Duan |
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| Institution: | 1.Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine 2.Shanghai University of Traditional Chinese Medicine |
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| Abstract: | Objective: To observe the influence of panax notoginseng flower saponins(PNFS) on c-myc and c-fos expressions in ET-1-induced human aortic vascular smooth muscle cells(HAVSC).Methods: Endothelin-1(ET-1) was used to induce HAVSC proliferation,and RT-PCR was employed to detect the c-myc and c-fos mRNA expressions.Results: PNFS could significantly inhibit HASMC c-myc mRNA expression(P<0.05),and could not influence c-fos mRNA expression.Conclusion: PNFS can suppress c-myc mRNA expression to inhibit HAVSC proliferation. |
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| Keywords: | Panax notoginseng flower saponins human aortic vascular smooth muscle cell c-myc c-fos |
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