| 5-羟色胺3A型受体在成年小鼠杏仁体基底外侧核中间神经元内的表达 |
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| 引用本文： | 林超,刘芳.5-羟色胺3A型受体在成年小鼠杏仁体基底外侧核中间神经元内的表达[J].神经解剖学杂志,2012,28(5):449-454. |
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| 作者姓名： | 林超 刘芳 |
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| 作者单位： | 复旦大学脑科学研究院,上海,200032 |
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| 基金项目： | 国家自然科学基金(30900425) |
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| 摘 要： | 目的:研究5-羟色胺3A型受体(5-HT3Areceptor;5-HT3AR)在杏仁体基底外侧核中间神经元内的表达。方法:以成年5-HT3AR-BACEGFP转基因小鼠作为材料,利用免疫组织化学技术在激光共聚焦显微镜下观察成年小鼠杏仁体基底外侧核中5-HT3AR在不同类型中间神经元内的表达。结果:杏仁体基底外侧核中分布着大量的5-HT3AR免疫阳性神经元。5-HT3AR在小鼠杏仁体基底外侧核中Calretinin(CR)、血管活性肠肽(Vasoactive in-testinal peptide,VIP)和Reelin免疫阳性的中间神经元中大量表达,而在Calbindin(CB)、Parvalbumin(PV)或Neu-ropeptide Y(NPY)免疫阳性的中间神经元中很少表达。结论:杏仁体基底外侧核中存在5-HT3AR免疫阳性中间神经元,不同类型的中间神经元中5-HT3AR的表达比例不同。
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| 关 键 词： | 杏仁体基底外侧核 5-羟色胺3A受体 中间神经元 5HT3AR-BACEGFP转基因小鼠 |
Identification of 5-HT type 3A receptor immunoreactive interneurons in the mouse basolateral amygdala |
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| Lin Chao
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Liu Fang.Identification of 5-HT type 3A receptor immunoreactive interneurons in the mouse basolateral amygdala[J].Chinese Journal of Neuroanatomy,2012,28(5):449-454. |
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| Authors: | Lin Chao Liu Fang |
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| Institution: | 1(Institutes of Brain Science,Fudan University,Shanghai,200032) |
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| Abstract: | Objective: To investigate the distribution of 5-HT type 3A receptor(5-HT3AR) in the mouse basolateral amygdala(BLA) interneurons.Methods: The distribution of 5-HT3AR in the BLA interneurons of adult 5-HT3AR-BACEGFP transgenic mice were explored by immunohistochemistry method with confocal laser scanning microscopy.Results: 5-HT3AR-immunopositive neurons were widely distributed in the BLA.5-HT3AR was expressed in calretinin(CR)-,vasoactive intestinal peptide(VIP)-or reelin-immunopostive interneurons,while it was less expressed in calbindin(CB)-,parvalbumin(PV)-or neuropeptide(NPY)-immunopositive interneurons.Conclusion: 5-HT3AR is expressed in different types of BLA interneurons,presenting differential ratios of 5-HT3AR-postive neurons in chemically distinctive interneurons. |
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| Keywords: | Basolateral amygdala 5-HT3AR 5HT3AR-BACEGFP transgenic mice Interneuron |
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