肝动脉栓塞化疗联合三维适形放疗治疗中晚期原发性肝癌临床疗效评价

目的探讨肝动脉栓塞化疗（TACE）结合三维适形放疗（3DCRT）对原发性肝癌（HCC）的临床疗效。方法按照入院的先后顺序，120例不能手术治疗的原发性肝癌患被随机分为观察组与对照组（n=60）。对照组给予单纯TACE治疗，观察组在TACE治疗的基础上行3DCRT治疗。对两组的总有效率（完全缓解＋部分缓解，即：CR＋PR）以及治疗后1、2、3年生存率等指标进行比较。结果观察组的总有效率为89.23％而对照组的总有效率为46.51％，组问差异具有统计学意义（P〈0.05）。2年生存率，观察组为58.3％，对照组为33.3％，组间比较差异具有统计学意义（X^2=8.471，P=0.005）；两组的1、3年生存率，观察组为68.3％和18.3％而对照组为65.0％和15.0％，组间比较差异无统计学意义（1年期X^2=1.83，X^2=0.233；3年期X^2=0.25，P=0.803）。结论TACE联合3DCRT治疗HCC的疗效较好，明显优于单纯的TACE治疗，具有重要的临床应用价值。

Transcatheter arterial chemoembolization combined three-dimensional conformal radiotherapy in treatment of primary liver cancer

Objective To explore the clinical efficacy of hepatic arterial embolization （TACE） combined with threedimensional conformal radiotherapy （3DCRT） for hepatocetlular carcinoma （HCC）. Methods According to the order of admission, 120 patients of unresectable hepatocellular carcinoma were randomly divided into observation group and control group （n=60）. Control group received TACE treatment alone, and the observation group in the TACE treatment based uplink 3DCRT treatment. On two recent overall response rate （complete response-l-partial remission, namely： CR＋PR）, and 1 year after treatment, two-year, 3-year survival and other efficacy measures were compared. Results The total effective rate of observation group and control group were 89.23% and 46.51%. There was a statistically significant difference between the groups （P〈0.05）. 2-year survival rate of observation group and control group were 58.3% and 33.3% （X^2 =8.471, P=0.005）. The 1-year and 3-year survival rate in the observation group were 65.0% and 15.0% and that of the control group was 68.3% and 18.3% （1-year X^2=l.83, P=0.233; 3-year X^2=0.25, P=0.803）. Conclusion TACE combined with 3DCRT was with good effect for hepatocellular carcinoma,.