帕珠沙星和左氧氟沙星治疗尿路感染的药物经济学评价

目的:对帕珠沙星和左氧氟沙星治疗尿路感染进行成本-效果分析。方法:选自本院就诊的尿路感染患者70例,随机分成两个治疗组:帕珠沙星组和左氧氟沙星组,运用药物经济学方法对两治疗组进行最小成本-效果分析比较。结果:帕珠沙星组和左氧氟沙星组的有效率分别为94.3%和88.6%,细菌清除率分别为91.4%和85.7%,不良反应发生率分别为5.71%和8.57%,均无显著差异(P>0.05),但成本-效果比分别为16.96和9.30,有显著差异(P<0.05)。结论:左氧氟沙星比帕珠沙星更具成本-效果优势,不失为治疗尿路感染的一种较为安全、有效且经济的选择。

Pharmacoeconomical Analysis of Pazufloxacin and Levofloxacin in Treatment of Urinary Tract Infection

Objective:To analyze the cost-effectiveness of pazufloxacin and levofloxacin in treatment of urinary tract infection. Methods: 70 cases with urinary infection were randomly divided into 2 groups,in which they were treated with pazufloxacin and levofloxacin, respectively. The cost-effectiveness in two groups was analyzed and compared with each other by pharmacoeconomical methods. Results: There was no significant diffe-rence in therapeutic effect between two groups(P>0.05),such as effective rates of 94.3% and 88.6%,bacterial clearance rates of 91.4% and 85.7% and undesired event rates of 5.71% and 8.57% in pazufloxacin group and levofloxacin group.However,there was significant difference in cost-effectiveness ratio between two group,16.96 and 9.30 respectively in pazufloxacin group and levofloxacin group (P<0.05). Conclusion: Levofloxacin has cost-effective advantage over pazufloxacin in the treatment of urinary tract infection.