| 大鼠实验性卡氏肺孢子虫肺炎中IL-2,IL-6的变化 |
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| 引用本文： | 周必英,戴晓煌,万启惠.大鼠实验性卡氏肺孢子虫肺炎中IL-2,IL-6的变化[J].地方病通报,2008,23(2):11-13. |
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| 作者姓名： | 周必英 戴晓煌 万启惠 |
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| 作者单位： | 贵州省遵义医学院寄生虫学教研室,贵州,遵义,563003 |
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| 摘 要： | 目的 建立大鼠实验性卡氏肺孢子虫肺炎的模型,观察血清和肺泡灌洗液中IL-2和IL-6的变化.方法 给SD大鼠皮下注射地塞米松磷酸钠建立卡氏肺孢子虫肺炎动物模型,酶免法检测支气管肺泡灌洗液中IL-2和IL-6含量及血清中IL-6含量;放免法检测血清中IL-2含量.结果 感染组大鼠血清和肺泡灌洗液中IL-2和IL-6含量均显著高于正常对照组.结论 卡氏肺孢子虫肺炎大鼠血清和肺泡灌洗液中IL-2和IL-6升高.
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| 关 键 词： | 卡氏肺孢子虫肺炎 |
| 文章编号： | 1000-3711(2008)02-0011-03 |
| 修稿时间： | 2008年1月28日 |
Change of IL-2 and IL-6 in Experimental Pneumocystis carinii Pneumonia in Rats |
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| ZHOU Bi-ying,DAI Xiao-huang,WAN Qi-hui.Change of IL-2 and IL-6 in Experimental Pneumocystis carinii Pneumonia in Rats[J].Endemic Diseases Bulletin,2008,23(2):11-13. |
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| Authors: | ZHOU Bi-ying DAI Xiao-huang WAN Qi-hui |
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| Abstract: | ObjectiveTo establish rat Pneumocystis carinii pneumonia(PCP) model and observe the change of interleukin-2(IL-2) and interleukin-6(IL-6) in sera and bronchoalveolar lavage fluid(BALF).MethodsSprague-Dawley(SD) rats were subcutaneously injected with dexamethasone sodium phosphate,the level of IL-2 and IL-6 in BALF and IL-6 in sera were detected by enzyme linked immunosorbent assay(ELISA);The level of IL-2 in sera was detected by radioimmunoassay(RIA).ResultsCompared with the normal control group,the level of IL-2 and IL-6 in sera and BALF of the infection group were significantly increased.ConclusionsThe level of IL-2 and IL-6 in sera and BALF increases in rat model of Pneumocystis carinii pneumonia. |
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| Keywords: | IL-2 IL-6 |
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