B型超声引导经皮经肝穿刺射频治疗肝癌的近期疗效

目的 评估集束电极射频（radiofrequency,RF)治疗肝癌的临床疗效及适应证。方法 回顾分析我院245例肝癌患者经集束电极射频治疗的临床资料，比较治疗前后癌体内血液供应状况，癌灶体积，胎甲球蛋白（AFP）的变化，及患者自觉症状的改善情况。结果 AFP术后1周内下降者占50％，患者自觉症状明显改善。癌灶直径小于5cm的肝癌，术后1至6个月内70％－90％癌灶血液供应消失，癌灶缩小，甚至消失。个别癌灶复发经再次射频治疗得到控制。直径大于5cm的肝癌，配合介入栓塞治疗，60％癌灶缩小。继发性肝癌，就癌灶而言，射频治疗术后癌灶缩小，症状得到控制。结论 B型超声引导下集束电极射频治疗肝癌近期疗效确切。直径小于5cm的癌灶疗效理想，直径大于5cm的肝癌，采用多点射频治疗，再配合介入栓塞治疗，也取得了比较理想的疗效。

Ultrasound guided radiofrequency ablation for liver carcinoma

Objective To evaluate the efficacy of ultrasonically guided radiofrequency (RF) thermal ablation of hepatic carcinoma (HC) with a clustered electrode. Methods Clinical records on 245 consecutively admitted HC patients who underwent RF tissue ablation therapy were analyzed. The tumor supplying blood flow, changes of tumor size, clinical manifestation, and AFP level were analyzed. Results AFP value decreased significantly in 50% of patients one week after ablation. Tumors less than 5*!cm in diameter became avascularized 1 to 6 months after the therapy, and it was noted that all tumors shrank in size after the therapy. For tumors more than 5*!cm in diameter, RF ablation was used in conjunction with intraarterial chemotherapy and embolization. Conclusion Ultrasound guided RF thermal ablation is an effective, safe, minimally invasive technique for treating malignant hepatic tumors.