百令胶囊联合贝那普利对早期糖尿病肾病患者尿白蛋白排泄率及C反应蛋白的影响

目的 观察百令胶囊联合贝那普利对糖尿病患者尿白蛋白排泄率（UAER）及C反应蛋白（CRP）水平的影响，探讨其对早期糖尿病肾病的保护作用。

Effect of Combined Therapy with Bailing Capsule and Benazepril on Urinary Albumin Excretion Rate and C-reactive Protein in Patients with Early Diabetic Nephropathy

Objective To observe the effect of combined therapy with Bailing Capsule（BC） and benazepril on the levels of urinary albumin excretion rate（UAER） and C-reactive protein（CRP） for exploring its protective effect on early diabetic nephropathy.Methods Sixty patients with early diabetic nephropathy were randomly assigned to the control group treated by benazepril alone,and the treated group treated by BC and benazepril,and the treatment lasted for 16 weeks.The changes of UAER and CRP levels were measured to estimate the protective effect of the combined therapy.Results Levels of 24h urinary protein,UAER,CRP were（0.85±0.32）g/24 h,（83.34±38.27）μg/min,（2.67±1.72）mg/L before treatment in the control group,and（0.43±0.17）g/24 h,（71.22±31.12）μg/min,（1.05±0.78）mg/L after treatment and they were（0.87±0.31）g/24 h,（81.59±35.69）μg/min,（2.55±1.66）mg/L before treatment in treated group,and（0.25±0.29）g/24 h,（57.32±31.11）μg/min,（0.49±0.38）mg/L after treatment recpectively,all of them decreased after treatment in both groups,showing significant differences as compared with those before treatment（P〈0.05,P〈0.01）,and the reduction in the treated group was more significant（P〈0.01）;meanwhile,levels of serum creatinine,fasting blood glucose and HbA1c had somewhat decrease,showing no statistical difference with those before treatment（P〉0.05）.Conclusion Combined use of BC and benazepril could significantly lower the UAER and CRP levels in patients with early diabetic nephropathy to alleviate the renal impairment,showing an effect better than that of using benazepril alone.