| 大鼠烧伤后急性期蛋白mRNA的表达 |
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| 引用本文： | 夏照帆,方勇.大鼠烧伤后急性期蛋白mRNA的表达[J].解放军医学杂志,1997,22(1):46-48. |
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| 作者姓名： | 夏照帆 方勇 |
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| 作者单位： | 第二军医大学长海医院 |
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| 摘 要： | 分析了不同烧伤程度大鼠肝、脾、肾和骨骼骨内４种急性期蛋白，即ａ１－酸性糖蛋白、ａ１－抗胰蛋白酶、白蛋白和转铁蛋白（Ｔｒｆ）ｍＲＮＡ水平的动态变化特征，结果表明：（１）肝脏是合成各种ＡＰＲ的主要场所；（２）即使是小面积的烧伤也可以诱发急性期反应。（３）烧伤后血清Ａｌｂ水平下降是急性期反应的特征，但在ｍＲＮＡ水平上并不下降而是增加。
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| 关 键 词： | 烧伤 mRNA APR AGP AT 急性期蛋白 表达 |
THE EFFECTS OF THERMAL INJURY ON mRNA EXPRESSION OF ACUTE PHASE REACTANTS IN RATS |
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| Xia Zhaofan,Fang Yong,Chen Yulin et al.THE EFFECTS OF THERMAL INJURY ON mRNA EXPRESSION OF ACUTE PHASE REACTANTS IN RATS[J].Medical Journal of Chinese People's Liberation Army,1997,22(1):46-48. |
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| Authors: | Xia Zhaofan Fang Yong Chen Yulin |
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| Institution: | Xia Zhaofan,Fang Yong,Chen Yulin et al .Changhai Hospital,The Second Military Medical University,Shanghai 200433 |
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| Abstract: | The dynamic changes in the levels of acute phase reactant(APR) mRNA in different tissue of rats receiving a 10% or 60% TBSA fullthickness burn were studied.The results of the study indicated that (1) the major site of APR synthesis was the liver;(2) even a small surface burn injury could elicit a rapid acute phase response,but the intensity of APR mRNA expression increased with the severity of the burn.(3) the down regulation of albumin mRNA,which was characteristic of the acute phase response,did not occur even though transfterrin (Trf) mRNA levels were significantly decreased. |
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| Keywords: | burns mRNA gene expressim regulation |
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