药物性肝炎临床研究

目的:分析56例药物性肝炎患者的病因及临床特点,以提高对该病的认识.方法:采用回顾性分析,对56例药物性肝炎住院患者的用药史、临床表现、肝功能检查、病原学标志物以及治疗转归等进行综合分析.结果:引起肝损害的药物中抗结核类药占26.79%,抗生素类药占21.43%,抗肿瘤类药占14.29%,中草药占12.50%,抗甲状腺类药占8.93%,降血脂类药占7.14%,糖尿病类药占5.36%,其他占3.57%.结论:(1)引起药物性肝炎的药物种类繁多,以抗结核药、抗肿瘤药、抗生素类药及中草药多见.(2)药物性肝炎临床表现与普通病毒性肝炎无明显特异性.(3)药物性肝炎肝功能检查显示GGT及ALP明显升高,可作为鉴别诊断的参考依据之一.

Clinical analysis of drug induced liver disease

Objective:To expand the knowledge of drug induced liver disease by analyzing the etiology and clinical features of 56 patients with drug induced liver disease.Methods:56 cases of drug induced liver damage admitted to our hospital from 2000 to 2005. They were reviewed with respect to their drug history,clinical symptoms and signs,liver function test,serum viral markers and therapeutic effect. Results:The drugs involved were anti-tuberculous agents in 26.79%,antibiotics in 21.43%,anti-tumor agents in 14.29%,herbal medicine in 12.50%,antithyroid agents in 8.93%,descendens blood fat drugs in 7.14%,diabetes drugs in 5.36%.Conclusion:(1)The various drugs may cause the druginduced liver disease.The most common drugs are anti-tuberculous agents,anti-tumorzgents,antibiotics and herbal medicine.(2)There is no obvious difference between the druginduced liver disease and viral hepatities.(3)In druginduced liver disease,liver function test shows that GGT and ALP raise up highly,It can be one of the reference bases in the differential diagniosis.