那屈肝素钙治疗不同发病时间的急性脑梗死

目的 :研究那屈肝素钙治疗不同发病时间脑梗死的疗效。方法 :5 0例发病 12h以内的脑梗死病人 ,随机分为治疗A组和对照A组各 2 5例 ;6 0例发病 12～ 4 8h ,随机分为治疗B组和对照B组各 30例。以上各组均予以丹参注射液 2 0mL +氯化钠注射液 2 5 0mL ,ivdrip ,qd。治疗组加用那屈肝素钙4 10 0IU ,sc ,q 12h。 4组疗程均 10d。治疗前、治疗后 1mo和 3mo测定病人神经功能缺损程度评分(NFDS)和日常生活活动能力评分 (ADL)。结果 :1mo和 3mo后 ,治疗A组和B组NFDS为 10± 4 ,5± 4和 13± 6 ,8± 3;与对照A组 (13± 5 ,10± 5 )和B组 (14± 7,12± 4 )比较 ,P <0 .0 5或P <0 .0 1。ADL评分和血液流变学指标各组均有改善 ,但以治疗A组尤为明显 ,P <0 .0 5或P <0 .0 1。结论 :那屈肝素钙能有效治疗急性脑梗死 ,早期应用效果更佳

Nadroparin calcium in patients with acute cerebral infarction in different course of diseases

AIM: To observe the effects of nadroparin calcium on patients with acute cerebral infarction in different course of disease. METHODS: Fifty patients with acute cerebral infarction attacked within 12 h were randomly divided into therapy A group (n=25) and control A group (n=25). Other sixty patients attacked within 12-48 h were randomly divided into therapy B group (n=30) and control B group (n=30). They were treated with Salvia Miltirrhiza Co 20 mL in 250 mL of 0.9 % sodium chloride injection, iv, drip, qd×10 d. On the basis of this treatment, patients in therapy A group and therapy B group were hypodermic injected (q 12 h) with nadroparin calcium (4 100 IU, sc) in abdomen. All patients were examined by hemorheological index and neurological function defect scale(NFDS) and Barthel index(ADL) before and after treatment. RESULTS: After treatment 1 mo, in therapy A group, control A group, therapy B group and control B group, the NFDS were 10±4, 13±5, 13±6 and 14±7. After treatment 3 mo, those were 5±4, 10±5, 8±3 and 12±4. The blood rheology was improved in all groups, but in therapy A group, it was much more obvious. CONCLUSION: Nadroparin calcium can produce a good therapeutic effect in treating cerebral infarction by improving blood rheology. It is more efficient if it is used in early stage.