辛伐他汀治疗蛛网膜下腔出血的疗效观察

目的探讨辛伐他汀对蛛网膜下腔出血治疗作用。方法将连平县人民医院2003年3月～2005年3月128例蛛网膜下腔出血的住院患者随机分为2组（所有病例均给以常规治疗并静脉注射尼膜地平）：治疗组（口服辛伐他汀组）64例，给予口服或者鼻饲辛伐他汀20mg，每日2次；对照组（常规治疗组）64例，给予安慰剂口服，每日2次。14d后对患者进行神经功能缺损评分并行头颅CT等检查。结果14d的治疗后治疗组较对照组神经功能缺损评分明显降低，二者比较差异有显著性意义（P〈0.05）。脑血管痉挛的发生率：治疗组为4例，对照组11例，二者比较有显著性意义（P〈0，01）。结论口服辛伐他汀能明显改善蛛网膜下腔出血后神经功能缺损评分。

Therapeutic effect of simvastatin on subarachnoid hemorrhage Z

Objective To explore the therapeutic effect of simvastatin on subarachnoid hemorrhage(SAH).Methods Totally 128 SAH patients,who were admitted to our hospital from March 2003 to March 2005,were randomly divided into 2 groups:simvastatin group(n=64)which were treated with routine therapy,intravenous injection of nimodipine and oral or nasal feed of 20 mg simvastatin,twice a day;control group(n=64)which were treated with routine therapy,intravenous injection of nimodipine and oral taking of placebo instead of simvastatin,twice a day.Two weeks later all patients were given neurologic impairment score and head CT.Results Neurologic impairment scores in simvastatin group were significantly lower than those of control group(P<0.05).The rate of cerebral vasospasm(CVS)is 6.25%(4/64)in simvastatin group and 17.19%(11/64)in control group,showing significant difference between the two(P<0.01).Conclusion Simvastatin can evidently improve the neurological function and the therapeutic outcomes after SAH.