CXCR4和VEGF—C在乳腺癌组织中的表达及与淋巴结转移之间的关系

目的探讨趋化因子受体（CXCR4）和血管内皮生长因子C（VEGF—C）在人乳腺癌组织中的表达及与淋巴结转移之间的关系。方法选择65例乳腺癌标本，应用免疫组织化学染色方法，检测CXCR4和VEGF—C在人乳腺癌组织中的表达，同时对其与临床病理参数的关系进行统计学分析。结果CXCR4在乳腺癌组织中的阳性表达率为43．1％，其中淋巴结转移组表达率为57．9％，无淋巴结转移组表达率为22．2％，差异有非常显著的统计学意义（P〈0．01）。VEGF—C在乳腺癌组织中的阳性表达率为50．2％，其中淋巴结转移组表达率为68．4％，无淋巴结转移组表达率为25．9％，两者差异非常显著（P〈0．01）。而且，CXCR4阳性表达与VEGF—C阳性表达呈显著正相关（P〈0．05）。乳腺癌CXCR4和VEGF—C的表达水平与乳腺癌淋巴结转移密切相关，而与病人的月经状态、临床分期、病理类型等无相关性（P〉0．05）。结论CXCR4和VEGF—C的表达可作为评估乳腺癌病人淋巴转移的一个观测指标。

Correlation of CXCR4 and VEGF-C expression with lymph node metastasis in breast carcinoma

Objective To investigate the relationship of chemokine receptor CXCR4 and vascular endothelial growth factor C （ VEGF - C ） with lymph node metastasis in breast carcinoma. Methods Immunohistochemistry was used to detect the expressions of CXCR4 and VEGF - C in 65 samples of breast carcinoma. The relationship between CXCR4, VEGF - C expressions and the eliniepathologieal parameters was statistically analyzed. Results The positive rate of CXCR4 expression with lymph node metastasis was higher than that without lymph node metastasis（ 57.9% vs 22.2% , P 〈 0.01 ）. The positive rate of VEGF - C expression with lymph node metastasis was higher than that without lymph node metastasis（68.4% vs25.9% , P 〈 0. 01 ）. The positive expression of CXCR4 was consistent with the positive expression of VEGF - C,and the expression levels of CXCR4 and VEGF- C were closely correlated with lymph node metastasis, but not with age, tumor size, histological type, cellular differentiation and invasion depth. Conclusion CXCR4 and VEGF - C expressions may become predictors for the lymphatic metastasis of breast carcinoma.