Dental manifestations in severe combined immunodeficiency following bone marrow transplantation |
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Authors: | Cole B O Welbury R R Bond E Abinun M |
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Affiliation: | Dept of Child Dental Health, Dental Hospital and School, Newcastle upon Tyne, UK. |
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Abstract: | Severe combined immunodeficiency (SCID) is a rare primary immunodeficiency disorder with an estimated overall frequency of 1 in 75 000 live births. Bone marrow transplantation is the only curative treatment available. Using T cell-depleted HLA non-identical bone marrow requires preconditioning with a short course of cytotoxic chemotherapy. We report severe dental developmental anomalies in three such patients under long-term follow up. |
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