星形细胞上调基因-1在肿瘤中的研究进展

星形细胞上调基因-1（AEG-1）最早于2002年被发现并成功克隆。AEG-1是一种癌基因，在多种肿瘤中高表达，与肿瘤分化、淋巴结转移、TNM分期和不良预后有关。AEG-1基因能激活PI3K／AKT、NF-κB、MAPK、Wnt等重要信号通路，通过改变下游基因的表达调控细胞的生理和病理过程，包括肿瘤的增殖、侵袭、转移、血管的形成及耐药性等。研究发现，AEG-1对于恶性肿瘤的诊断及预后的判断具有重要的参考价值，其有望成为肿瘤预后评估的重要指标及基因治疗的新靶点。

Progression of astrocyte elevated gene-1 in tumor

Astrocyte elevated gene-1 （ AEG-1 ） was initially identified and cloned in 2002. It has been proved to be an onco- gene. AEG-1 has been reported that it is highly expressed in various types of human cancer, and is positively correlated with tumor dif- ferentiation, lymph node metastasis, TNM staging and negatively correlated with prognosis. AEG-1 over-expression activates the PI3K/ AKT, NF-KB, MAPK and Wnt signaling pathways in several crucial aspects of the molecular mechanism. AEG-1 plays an important role in the regulation of physiological and pathological process in tumor, including proliferation, invasion, metastasis, formation of the blood vessels and drug-resistance. Based on the research findings, AEG-1 has important reference value for diagnosis and prognosis predicting of malignant tumor, and it represents a viable potential target for the prognostic judgement and the therapy of tumor.