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| 成年大鼠脊髓全横断损伤后酪氨酸激酶受体C在脊髓和大脑皮层的表达 | |
| 引用本文： | 钱东翔,张洪钿,蔡颖谦,罗鹏,徐如祥. 成年大鼠脊髓全横断损伤后酪氨酸激酶受体C在脊髓和大脑皮层的表达[J]. 神经科学通报, 2011, 27(2): 83-90. DOI: 10.1007/s12264-011-1150-1 |
| 作者姓名： | 钱东翔 张洪钿 蔡颖谦 罗鹏 徐如祥 |
| 作者单位： | 广州医学院第三附属医院神经外科;广东省脑功能修复与再生重点实验室广东神经外科研究所南方医科大学;中国人民解放军北京军区总医院神经外科 |
| 基金项目： | supported by the grants from National Natural Science Foundation of China (No. U0632008);the Key Project of Science and Technology Research Foundation of Guangdong Province,China (No. 2008A030201019,2007-05/06-7005206);the Key Project of Science and Technology Research Foundation of Guangzhou municipality,China (No. 09B52120112,2008A1-E4011-6);the Foundation for Medical and Scientific Technology Research of Guangdong Province,China (No. A2009293) |
| 摘 要： | 目的 研究神经营养因子3(neurotrophin-3,NT-3)的受体-酪氨酸激酶受体C(tyrosine kinase receptor C,TrkC)在脊髓损伤(spinal cord injury,SCI)后神经重塑中的作用.方法 研究脊髓全横断损伤大鼠手术后第1、3、7和14 d时,低位胸髓节段和大脑中央前回... |
| 关 键 词： | 酪氨酸激酶受体C 脊髓损伤 可塑性 mRNA |
| 收稿时间： | 2010-12-13 |
Expression of tyrosine kinase receptor C in the segments of the spinal cord and the cerebral cortex after cord transection in adult rats |
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| Dong-Xiang Qian,Hong-Tian Zhang,Ying-Qian Cai,Peng Luo,Ru-Xiang Xu. Expression of tyrosine kinase receptor C in the segments of the spinal cord and the cerebral cortex after cord transection in adult rats[J]. Neuroscience Bulletin, 2011, 27(2): 83-90. DOI: 10.1007/s12264-011-1150-1 | |
| Authors: | Dong-Xiang Qian Hong-Tian Zhang Ying-Qian Cai Peng Luo Ru-Xiang Xu |
| Affiliation: | 1. Department of Neurosurgery, the Third Affiliated Hospital, Guangzhou Medical College, Guangzhou, 510150, China 2. Institute of Neurosurgery, Key Laboratory on Brain Function Repair and Regeneration of Guangdong, Southern Medical University, Guangzhou, 510282, China 3. Department of Neurosurgery, the Military General Hospital of Beijing PLA, Beijing, 100700, China |
| Abstract: | ObjectiveTo investigate the role of tyrosine kinase receptor C (TrkC), the receptor of neurotrophin-3 (NT-3), in neuroplasticity following spinal cord injury (SCI).MethodsRats with cord transection were allowed to survive for 1, 3, 7 and 14 d post operation (dpo). TrkC expressions at lower thoracic levels of the spinal cord and in precentral gyrus of cerebral cortex were investigated.ResultsTrkC protein levels at both the site of injury (T10–T11) and the neighboring segments (T9 and T12) in the spinal cord decreased significantly at 1-7 dpo, followed by a rapid increase at 14 dpo. The temporal changes in TrkC mRNA expression level showed a similar pattern with that of TrkC protein. In addition, the levels of TrkC protein and mRNA at the site of injury (T10–T11) were significantly higher than those at the neighboring spinal segments (T9 and T12). Besides, the levels of TrkC protein and mRNA were higher at the rostral segment than at the caudal segment. However, in the motor cortex, TrkC protein was not detected and TrkC mRNA was expressed at a very low level.ConclusionThese results suggest that TrkC may be involved in neuroplasticity after SCI. |
| Keywords: | tyrosine kinase receptor C spinal cord injury plasticity mRNA |
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