儿童情绪与哮喘病情的关系及对IL-8的影响

支气管哮喘是儿童期较常见的一种变态反应性疾病 ,我国小儿哮喘的患病率为 0 .5 %～ 2 % ,个别地区高达 5 %。儿童哮喘的诱发因素除过敏、感染等之外 ,有相当部分与社会心理因素有关。对不易控制的哮喘发作者 ,情绪或行为的紊乱本身与疾病病情关系甚为密切。本研究采用《儿童状态 -特质焦虑问卷》(ＳＴＡ ＩＣ)和《儿童抑郁障碍自评量表》(ＳＤＤＳＣ)对 4 0例轻、中度哮喘患儿的情绪状态进行评定 ,同时采用有效的非创伤性方法检测了其中 33例患儿痰液白细胞介素 - 8(ＩＬ - 8)水平 ,观察不同严重度哮喘患儿的情绪状态及其与痰中ＩＬ - 8水…

Relationship between Emotion, Severity of Illness and the Effect on IL-8 in Asthmatic Children

Objective: To examine the emotional states of asthmatic children with different degrees of severity, as well as the effects of emotion on change of cytokines in airway. Methods: Asthmatic children were divided into two groups according to the degrees of severity: moderate and mild. Their emotional states were measured and results were compared. Correlation analysis was conducted between scores on emotional scales and sputum levels of IL-8.Results: Total scores on anxiety and depression were higher in the moderate group than in the mild group. Negative correlation was found between levels of anxiety and IL-8 during acute exacerbation of asthmatic condition. Conclusion: Emotional distress was found to be increased with severity of asthmatic condition in children. Anxiety contributed to the decreased concentration of IL-8 in asthmatic children's airway.