| 川芎嗪芳酸醚甘氨酸衍生物合成及抗血小板聚集活性 |
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| 引用本文： | 邬皓,李家明,盛日正,周鹏,钟国琛,蒋丽娜. 川芎嗪芳酸醚甘氨酸衍生物合成及抗血小板聚集活性[J]. 安徽医药, 2011, 15(8): 937-940 |
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| 作者姓名： | 邬皓 李家明 盛日正 周鹏 钟国琛 蒋丽娜 |
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| 作者单位： | 安徽中医学院药学院,安徽省现代中药重点实验室,合肥,230031;安徽大学,安徽,合肥,230601 |
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| 基金项目： | 国家科技重大专项重大新药创制项目(批准号:2009ZX09103-123); 安徽省高校自然基金重点项目(批准号:KJ2010A206) |
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| 摘 要： | 目的 合成一系列新的甘氨酸衍生物,并初步筛选其抗血小板聚集活性.方法 以川芎嗪、甘氨酸、阿魏酸等芳酸为起始原料,经过一系列反应,合成得到目标化合物.结果 合成了6个川芎嗪芳酸醚类甘氨酸衍生物,其结构均经IR、1H-NMR、13C-NMR和MS确证.结论 所有目标化合物均未见文献报道.药理结果初步显示化合物1a、1b、1...
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| 关 键 词： | 川芎嗪 甘氨酸 抗血小板聚集 化学合成 |
Synthesis of a series of glycine derivatives ligustrazine-aromatic acid and their inhibitory effects on platelet aggregation |
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| WU Hao,LI Jia-ming,SHENG Ri-zheng,ZHOU Peng,ZHONG Guo-chen,JIANG Li-na. Synthesis of a series of glycine derivatives ligustrazine-aromatic acid and their inhibitory effects on platelet aggregation[J]. Anhui Medical and Pharmaceutical Journal, 2011, 15(8): 937-940 |
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| Authors: | WU Hao LI Jia-ming SHENG Ri-zheng ZHOU Peng ZHONG Guo-chen JIANG Li-na |
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| Affiliation: | WU Hao1,LI Jia-ming1,SHENG Ri-zheng1,ZHOU Peng1,ZHONG Guo-chen1,JIANG Li-na2(1.Department of Pharmacy,Anhui College of Traditional Chinese Medicine,Anhui Key Laboratory of Traditional Chinese Medicine,Hefei,Anhui 230031,2.Anhui University,Anhui 230601,China) |
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| Abstract: | Aim To synthesize a series of new glycine derivatives and to study their inhibitory effects on platelet aggregation.Methods The target compounds were synthesized from Ligustrazine,glycine,ferulic acid and its analogs via a series of reactions.Results Six target compounds were synthesized.Their structures were characterized by IR,1H-NMR,13C-NMR and MS.Conclusions The target compounds have not been reported in literatures.Preliminary pharmacological results show that the inhibitory effect on platelet aggregat... |
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| Keywords: | ligustrazine glycine platelet aggregation inhibitory synthesis |
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