米非司酮在妊娠7～10周人工流产手术中的应用与疗效观察

目的观察米非司酮在妊娠7～10周人工流产手术中应用的临床效果。方法 120例自愿要求人工流产终止妊娠的早孕妇女,孕周在7～10周,孕囊最大横径大于40 mm。随机分为观察组和对照组各60例,观察组在术前48 h口服米非司酮胶囊(Ⅱ)50 mg,然后行B超导视下无痛负压吸引术;对照组术前不服用米非司酮,行B超导视下无痛负压吸引术。观察2组术中出血量、手术时间、术后子宫复旧和并发症。结果观察组术中出血量少于对照组,手术时间短于对照组,术后子宫复旧好于对照组,差异均有统计学意义(P<0.05)。结论米非司酮应用于孕周7～10周,孕囊最大横径≥40 mm的人工流产术,能减少术中出血量,缩短手术时间,促进子宫复旧,且无明显不良反应,可在临床推广应用。

Application and observation of mifepristone in abortion with the gestational age of 7~10 weeks

Aim To observe clinical effect of mifepristone in abortion with the gestational age of 7～10 weeks.Methods 120 cases of pregnancy women who voluntarily require abortion were randomly divided into observation group and the control group 60 cases of each,with the gestational age of 7～10 weeks.The biggest diameter p pregnancy sac was 40 mm.The observe group in the 48 h before abortion was given mifepristone（Ⅱ）50 mg 2 hours fasting before and after medication.The control group did not take before surgery mifepristone,only visible induced abortion.Observation was made of the operative time and blood loss of 2 groups,uterine instauration and the postoperative complications.Results The observation group less blood loss,had shorter operation time than the control group.The differences were statistically significant（P〈0.05）.The observation group had better uterine instauration than the control group.The differences were statistically significant（P〈0.05）.Conclusion Mifepristone for abortion,with the gestational age of 7～10 weeks,the biggest diameter p pregnancy sac 40 mm surgical decompression miscarriage can fully reduce operating time,has less blood loss,promote uterine instauration,without significant adverse reactions,can be clinically applied.