PARP inhibitors: its role in treatment of cancer |
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Authors: | Chen Alice |
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Affiliation: | Alice Chen Division of Cancer Treatment and Diagnosis National Institutes of Health,National Cancer Institute,Rockville,MD 20852,USA |
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Abstract: | PARP is an important protein in DNA repair pathways especially the base excision repair (BER). BER is involved in DNA repair of single strand breaks (SSBs). If BER is impaired, inhibiting poly(ADP-ribose) polymerase (PARP), SSBs accumulate and become double stand breaks (DSBs). The cells with increasing number of DSBs become more dependent on other repair pathways, mainly the homologous recombination (HR) and the nonhomologous end joining. Patients with defective HR, like BRCA-deficient cell lines, are even... |
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Keywords: | PARP BRCA PARP inhibitors |
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