| 雷诺嗪缓释片体外释放度的测定 |
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| 引用本文： | 贾晶莹,刘罡一,张梦琪,陆川,余琛,蒋新国. 雷诺嗪缓释片体外释放度的测定[J]. 安徽医药, 2011, 15(8): 951-952 |
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| 作者姓名： | 贾晶莹 刘罡一 张梦琪 陆川 余琛 蒋新国 |
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| 作者单位： | 复旦大学药学院药剂学教研室,上海,201203;上海市徐汇区中心医院,上海,200031;上海市徐汇区中心医院,上海,200031;复旦大学药学院药剂学教研室,上海,201203 |
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| 摘 要： | 目的建立雷诺嗪缓释片的体外释放度测定方法。方法以0.9%的盐酸水溶液为溶出介质,溶出方法为转篮法(100 r.min-1)。结果采用紫外分光光度法在272 nm测定雷诺嗪的浓度,其检测线性范围为10～200 mg.L-1(r=0.999 9),平均回收率为98.04%(RSD=1.26%);3批样品在2、6、12 h的释放量分别为标示量的30%、60%、70%以上。结论该方法准确、可靠,可用于该制剂的释放度测定。
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| 关 键 词： | 雷诺嗪 释放度 紫外分光光度法 |
In vitro dissolution of ranolazine sustained-release tablets |
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| JIA Jing-ying,LIU Gang-yi,ZHANG Meng-qi,LU Chuan,YU Chen,JIANG Xin-guo. In vitro dissolution of ranolazine sustained-release tablets[J]. Anhui Medical and Pharmaceutical Journal, 2011, 15(8): 951-952 |
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| Authors: | JIA Jing-ying LIU Gang-yi ZHANG Meng-qi LU Chuan YU Chen JIANG Xin-guo |
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| Affiliation: | JIA Jing-ying1,2,LIU Gang-yi1,ZHANG Meng-qi2,LU Chuan2,YU Chen2,JIANG Xin-guo1 (1.Department of Pharmaceutics,School of Pharmacy,Fudan University,Shanghai 201203,China,2.Shanghai Xuhui Central Hospital,Shanghai 200031,China) |
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| Abstract: | Aim To establish a method for the determination of the dissolution of ranolazine sustained-release tablets.Methods Ranolazine sustained-release tablet was dissolved in 0.9 % HCL medium with stirring basket method at 100 r· min-1.Results Calibrations between 10～200 mg· L-1 exhibited consistent linearity and reproducibility（r=0.999 9）.The wavelength was 272 nm,and the average recovery rate was 98.04 %（RSD = 1.26 %）.3 batch of samples approved the dissolutions of 2,6,12 h were all above 30%,60%,70%,respectively.Conclusion This method is accurate,reliable and can be used for the preparation of the dissolution of ranolazine sustained-release tablet. |
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| Keywords: | ranolazine release rate ultraviolet spectrophotometry |
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