MK因子在不同病理类型宫颈癌组织的表达及临床意义

目的:探讨MK因子(中期因子)在宫颈癌的表达与临床病理特征的关系。方法:用免疫组织化学法(SP法)检测178例宫颈癌组织和74例宫颈上皮内瘤变组织中MK因子的表达。结果:178例宫颈癌组织中,MK蛋白阳性表达率为91.57%,明显高于宫颈上皮内瘤样病变组织的14.86%(P<0.001)。宫颈癌临床分期不同MK蛋白阳性表达率不同,临床Ⅰ期阳性表达率显著低于临床Ⅱ~Ⅳ期(P<0.001)。宫颈鳞癌MK阳性表达率显著高于腺癌(P<0.001),但与组织分化程度无关(P=0.123)。有盆腔淋巴结转移者MK阳性表达率显著高于无盆腔淋巴结转移者(P=0.026)。结论:MK因子阳性表达与宫颈癌病理特征关系密切,可能成为一种有价值的肿瘤标志物,对宫颈癌的早期诊断及治疗有一定的临床指导意义。

The expression of midkine factor and the clinical significance in different categories of pathology in cervical cancer

Objective:To investigate the relationship between the expression of midkine(MK) factor and characters of clinical pathology in cervical cancer.Methods:The expression of MK was detected by immunohistochemistry in 178 cervical cancer specimens and 74 cervical intraepithelial neoplasia specimens.Results:The positive expression rates of MK were 91.57% and 14.86% for cervical cancer and cervical intraepithelial neoplasia,respectively.The significance different was observed between cervical cancer and cervical intraepithelial neoplasia(P<0.001).The positive expression rates were different among clinical stages.The positive expression rate in clinical stage Ⅰ was significantly lower than that in clinical stageⅡ~Ⅳ(P<0.001).The positive expression rate in squamous carcinoma was higher than that in adenocarcinoma(P<0.001).But the significance different was not found among degrees of histodifferentiation(P=0.123).The positive expression rate was significantly higher in the patients with metastasis to celiac lymph nodes than that of without(P=0.026).Conclusion:There was a closely relationship between the positive expression of MK and character of clinical pathology in cervical cancer and it may be used as a kind of worthy tumor markers.