Isolation, structural elucidation, and cytotoxicity of three new ent-kaurane diterpenoids from Isodon japonica var. glaucocalyx |
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Authors: | Liang Hui-Juan Zhang Yun-Xiao Hai Guang-Fan Bai Su-Ping Yuan Yong-Liang Ye Dan-Dan Zhou Nan-Qian |
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Institution: | School of Pharmacy, Xinxiang Medical University, Xinxiang, Henan, P. R. China. |
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Abstract: | Three new ENT-kaurane diterpenoids, glaucocalyxin H ( 1), glaucocalyxin I ( 2), and glaucocalyxin J ( 3), together with four known diterpenoids ( 4- 7), were isolated from the leaves of Isodon japonica Hara var. glaucocalyx. Their structures were elucidated by spectroscopic analysis, and the structures of compounds 2 and 3 were further confirmed by X-ray crystallographic analysis. Compounds 1, 4, and 5 were evaluated for their cytotoxicity IN VITRO against CE-1, U87, A-549, MCF-7, Hela, K-562, and HepG-2 human tumor cell lines. Compound 1 showed potent inhibitory activities against six tumor cell lines with IC (50) values ranging from 1.86-10.95 μM, and compounds 4 and 5 exhibited significant selective cytotoxicity on seven tumor cell lines. |
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