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MSI as a predictive factor for treatment outcome of gastroesophageal adenocarcinoma |
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| Institution: | 1. Department of Medical Oncology, Cancer Center Amsterdam, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands;3. Department of Pathology, Cancer Center Amsterdam, Amsterdam University Medical Centers, VU University, Amsterdam, the Netherlands;4. Department of Medical Oncology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands;5. Department of Medical Oncology, Cancer Center Amsterdam, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands |
| Abstract: | Gastroesophageal cancers are a major cause of death worldwide and treatment outcomes remain poor. Adequate predictive biomarkers have not been identified.Microsatellite instability (MSI) as a result of mismatch repair deficiency is present in four to twenty percent of gastroesophageal cancers and has been associated with favorable survival outcomes compared to microsatellite stable tumors. This prognostic advantage may be related to immunosurveillance, which may also explain the favorable response to immune checkpoint inhibition observed in MSI high (MSI-H) tumors. The value of conventional cytotoxic treatment in MSI-H tumors is unclear and results on its efficacy range from detrimental to beneficial effects.Here the recent data on MSI as a predictive factor for outcome of gastroesophageal cancer treatment is reviewed. |
| Keywords: | Gastroesophageal cancer Microsatellite instability Mismatch repair deficiency Chemotherapy Immunotherapy Checkpoint inhibition |
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