Dietary N-3 PUFA deficiency affects sleep-wake activity in basal condition and in response to an inflammatory challenge in mice |
| |
Institution: | 1. Institute of Psychiatry, Psychology and NeuroscienceKing’s College LondonCutcombe RoadLondon SE5 9RTUKJane.chang@kcl.ac.uk________________________________________;2. GeneralChina Medical University#2, Yuh-Der Rd,Taichung404Taiwancobolsu@gmail.com+886 4 2206 2121 ext 4126;1. University of Waikato, Hamilton, New Zealand;2. Dairy Goat Co-operative (NZ) Ltd, Hamilton, New Zealand;3. Department of Food Science and Nutrition, University of Minnesota, St. Paul, MN, USA;1. Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States;2. Inflammation Research Foundation, Marblehead, MA, United States;3. Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH, United States;1. Cognitive and Neuroscience Reserch Center (CNRC), Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran;2. Department of Biology, Faculty of Basic Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran;3. Department of Pharmacology School of Medicine, Tehran University of Medical Sciences, Tehran, Iran;4. Iranian National Center for Addiction Studies, Tehran University of Medical Sciences, Tehran, Iran;5. Department of Neuroendocrinology, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran;1. Case Western Reserve University, School of Nursing, 10900 Euclid Avenue, Cleveland, OH 44106, United States;2. University of California, Neuropathology, Department of Pathology, 9500 Gilman Drive, La Jolla, San Diego, CA 92093, United States;3. Emory University, School of Medicine, Department of Neurology, Woodruff Memorial Research Building, 101 Woodruff Circle NE (Clifton RD NE), Atlanta, GA 30322, United States;1. School of Mental Health, Wenzhou Medical University, Wenzhou 325035, China;2. The Affiliated Kangning Hospital, Wenzhou Medical University, Wenzhou 325035, China;3. Department of Biomedical Engineering, College of Engineering, Peking University, Beijing 100871, China;4. The Second Affiliated Hospital, Xinjiang Medical University, Urumqi 830063, China;5. Psychosomatic Medicine Research Division, Inner Mongolia Medical University, Huhhot 010110, China;6. Beijing Jishuitan Hospital, Beijing 100035, China;7. The Affiliated Wenling Hospital of Wenzhou Medical University, Wenling 317500, China;8. Department of Psychiatry & Mind-Body Interface Laboratory (MBI-Lab), China Medical University Hospital, Taichung, Taiwan;9. College of Medicine, China Medical University, Taichung, Taiwan;10. An-Nan Hospital, China Medical University, Tainan, Taiwan;11. Beijing Hui-Long-Guan Hospital, Peking University, Beijing 100096, China |
| |
Abstract: | Essential polyunsaturated fatty acids (PUFA) from the n-3 and n-6 series constitute the building blocks of brain cell membranes where they regulate most aspects of cell physiology. They are either biosynthesized from their dietary precursors or can be directly sourced from the diet. An overall increase in the dietary n-6/n-3 PUFA ratio, as observed in the Western diet, leads to reduced n-3 PUFAs in tissues that include the brain. Some clinical studies have shown a positive correlation between dietary n-3 PUFA intake and sleep quantity, yet evidence is still sparse. We here used a preclinical model of dietary n-3 PUFA deficiency to assess the precise relationship between dietary PUFA intake and sleep/wake activity. Using electroencephalography (EEG)/electromyography (EMG) recordings on n-3 PUFA deficient or sufficient mice, we showed that dietary PUFA deficiency affects the architecture of sleep-wake activity and the oscillatory activity of cortical neurons during sleep. In a second part of the study, and since PUFAs are a potent modulator of inflammation, we assessed the effect of dietary n-3 PUFA deficiency on the sleep response to an inflammatory stimulus known to modulate sleep/wake activity. We injected mice with the endotoxin lipopolysaccharide (LPS) and quantified the sleep response across the following 12 h. Our results revealed that n-3 PUFA deficiency affects the sleep response in basal condition and after a peripheral immune challenge. More studies are now required aimed at deciphering the molecular mechanisms underlying the intimate relationship between n-3 PUFAs and sleep/wake activity. |
| |
Keywords: | Omega-3 DHA Sleep Slow wave activity EEG LPS Inflammation |
本文献已被 ScienceDirect 等数据库收录! |
|