Urinary bisphenol A concentrations and in vitro fertilization outcomes among women from a fertility clinic |
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| Affiliation: | 1. “Gameta”, 7 Cybernetyki St, Warsaw, 02-677, Poland;2. “Gameta” Kielce-Regional Science-Technology Centre, Kielce, 45 Podzamcze St, Chęciny, 26-060, Poland;3. Department of Toxicology, Medical University of Gdańsk, 107 Hallera St, Gdańsk, Poland;4. Department of Gynecology and Reproduction, “Gameta” Hospital, 34/36 Rudzka St, 95-030 Rzgów, Poland;5. Faculty of Health Sciences, The State University of Applied Sciences in Plock, 2 Dabrowskiego Sq, 09-402 Plock, Poland;6. Department of Hygiene and Epidemiology, Medical University of Lodz, Zeligowskiego 7/9 St, Łódź, 90-752, Poland;1. Research in Female Reproduction Postgraduate Course, National and Kapodistrian University of Athens Medical School, Athens, Greece;2. Unit of Reproductive Endocrinology, 1st Department of Obstetrics and Gynecology, Aristotle University of Thessaloniki, Greece;3. Department of Clinical Biochemistry, “Aghia Sophia” Children''s Hospital, Athens, Greece;1. Department of Environmental Health Sciences, University at Albany, State University of New York, Rensselaer, NY, United States;2. Department of Obstetrics, Gynecology and Reproductive Sciences, University of California at San Francisco, San Francisco, CA, United States;3. Department of Epidemiology and Biostatistics, University at Albany, State University of New York, Rensselaer, NY, United States;4. Department of Global and Community Health, George Mason University, Fairfax, VA, United States;1. National Laboratory on Endocrine Disruptors of Interuniversity Consortium INBB, Italy;2. Institute of Genetics and Biophysics (IGB) “ABT”, National Research Council (CNR), Via P. Castellino, 111, 80131, Naples, Italy;3. Department of Gynaecology, Obstetric and Reproductive Science, Second University of Studies of Naples, Naples, Italy;4. Department of Biology, University “Federico II” of Naples, Naples, Italy;5. Institute of Biosciences and Bioresources (IBBR), National Research Council (CNR), Naples, Italy;1. NPFPC Key Laboratory of Contraceptives and Devices, Department of Reproductive Epidemiology and Social Science, Shanghai Institute of Planned Parenthood Research, Shanghai, China;2. Department of Occupational Health and Toxicology, School of Public Health, WHO Collaborating Center for Occupational Health, Fudan University, Shanghai, China;3. Department of Epidemiology, Shanxi Medical University, Taiyuan, China;4. University of Science and Technology of China, Hefei, China;5. Division of Research, Kaiser Foundation Research Institute, Kaiser Permanente, Oakland, CA, USA;6. Department of Health Research and Policy, School of Medicine, Stanford University, Stanford, CA, USA;1. Department of Environmental Health Sciences, School of Public Health and Health Sciences, University of Massachusetts, 686 North Pleasant Street, Amherst, MA 01003, United States;2. Department of Obstetrics Gynecology and Reproductive Biology, Division of Maternal Fetal Medicine Brigham and Women''s Hospital, 75 Francis Street, Boston, MA 02115, United States;3. Division of Reproductive Endocrinology and Infertility, Baystate Medical Center, 759 Chestnut Street, Springfield, MA 01199, United States |
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| Abstract: | Bisphenol A (BPA) is a widespread environmental endocrine disrupting chemical. Although many animals and in vitro studies reported that BPA may affect female fertility through the effect on maturing oocytes and meiotic cell division, but the data from human studies are limited and inconclusive. The study was conducted to examine the association between urinary BPA concentration and in vitro reproductive outcomes (metaphase II (MII) oocyte yield, top quality embryo, fertilization rate, implantation rate and clinical pregnancy) among women from an infertility clinic.The study participants were enrolled in the Infertility Center in Poland. 450 women aged 24-44 (n = 674 IVF cycles) provided urine samples. The urinary concentrations of BPA were evaluated using validated gas chromatography ion-tap mass spectrometry method. Clinical outcomes of IVF treatment were abstracted from patients electronic chart records. To assess the relationship between urinary BPA concentrations early examined reproductive outcomes generalized linear mixed models were used.The detection rate of BPA in urine samples was 98% and the geometric mean 1.59 ± 2.15 ng/ml. A significant decrease was observed between urinary concentration of BPA and implantation (p = 0.04) and decreased MII oocyte count (p = 0.03). There was no association between other examined IVF outcomes: embryo quality, fertilization rate and clinical pregnancy and BPA exposure.Exposure to BPA may have a negative effect during the early stages of human development. The studies among the larger and more diverse population are needed to confirm the results. |
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| Keywords: | early IVF outcomes urinary bisphenol A concentrations infertility treatment |
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