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| 清开灵注射液对急性肺损伤大鼠肺组织及CD4^＋T细胞数目的影响 | |
| 引用本文： | 张平,张书杰,何平平,李杰平,肖华,唐国华. 清开灵注射液对急性肺损伤大鼠肺组织及CD4^＋T细胞数目的影响[J]. 南华大学学报(医学版), 2008, 36(1): 22-24 |
| 作者姓名： | 张平 张书杰 何平平 李杰平 肖华 唐国华 |
| 作者单位： | 1. 南华大学,第一附属医院,呼吸内科,湖南,衡阳,421001;南华大学,护理学院 2. 南华大学,第一附属医院,呼吸内科,湖南,衡阳,421001 3. 南华大学,医学院流式细胞室 |
| 基金项目： | 衡阳市科学技术局科研基金 |
| 摘 要： | 目的探讨清开灵注射液对急性肺损伤大鼠免疫功能的影响。方法32只sD雄性大鼠随机分4组（对照组、模型组、治疗组、预防组），每组8只；各组均从尾静脉注药。对照组：注入1mL生理盐水；模型组：注入内毒素5mg／kg；治疗组：注入内毒素5mg／kg，45min后，注入清开灵注射液0.05mL／kg；预防组：注入清开灵注射液0．05mL／kg，45min后，注入内毒素5mg／kg。从第一次注液起5h后，取外周血2mL肝素抗凝，流式细胞仪测大鼠外周血中CD4^＋T细胞、CD8^＋T细胞数目及CD4^＋／CD8^＋的比值。结果CD4^＋T细胞数目、CD4^＋／CD8^＋的比值在各组之间差异均有显著性（P〈0．05）。结论清开灵注射液对大鼠急性肺损伤具有明显的修复作用，其机制可能与增加CD4^＋T细胞数目、改善CD4^＋／CD8^＋比例有关。 |
| 关 键 词： | 急性肺损伤 清开灵注射液 肺组织 |
Effect of QingKaiLing Injection On Lung Tissue and the Number of CD4+ of Mice With Acute Lung Injury |
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| ZHANG Ping,ZHANG Shu-jie,He Ping-ping,et al. Effect of QingKaiLing Injection On Lung Tissue and the Number of CD4+ of Mice With Acute Lung Injury[J]. Journal of Nanhua University(Medical Edition), 2008, 36(1): 22-24 | |
| Authors: | ZHANG Ping ZHANG Shu-jie He Ping-ping et al |
| Affiliation: | ZHANG Ping,ZHANG Shu-jie,He Ping-ping,et al(Department of Respiratory Medicine,the First Affiliated Hospital,Nanhua University,Hengyang,Hunan 421001,China) |
| Abstract: | Objective To explore the effect of QingKaiLing injection on immune function of acute lung injury mice. Methods Thirty-two Cleare-animal mice were divided into four groups(normal group,model group,treatment group and defence group).All mice were injected from tail vein.Normal group:injected with 1mL saline;Model group:injected with lipopolysaccharide(5 mg/kg).Treatment group: injected with lipopolysaccharide(5 mg/kg),after 45 minutes,injected with Qingkailing injection(0.5 g/kg).Defence group: injected with ... |
| Keywords: | acute lung injury Qingkailing injection lung tissue |
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