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Inhibition of NF-κB activation by 5-lipoxygenase inhibitors protects brain against injury in a rat model of focal cerebral ischemia |
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| Authors: | Manu Jatana Shailendra Giri Mubeen A Ansari Chinnasamy Elango Avtar K Singh Inderjit Singh Mushfiquddin Khan |
| Affiliation: | (1) Department of Pediatrics, Medical University of South Carolina, Charleston, SC 29425, USA;(2) Department of Pathology and Laboratory medicine, Ralph H. Johnson VA Medical Center Charleston, SC 29425, USA |
| Abstract: | BackgroundStroke is one of the leading causes of death worldwide and a major cause of morbidity and mortality in the United States of America. Brain ischemia-reperfusion (IR) triggers a complex series of biochemical events including inflammation. Leukotrienes derived from 5-lipoxygenase (5-LOX) cause inflammation and are thus involved in the pathobiology of stroke injury. |
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