In vivo effect of proton-pump inhibitors on gastric plasmin-dependent fibrinolysis: A study in a porcine model |
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Authors: | Aurelie Thibault Philippe Marteau Ludovic Drouet Anne Lavergne Slove Claire Bal dit Sollier Marine Camus Xavier Dray |
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Affiliation: | 1. Denis Diderot, Paris 7 University, and AP-HP, Department of Digestive Diseases, and School of Surgery, Paris, France;2. Department of Gastroenterology, Carémeau Hospital, Nîmes, France;3. Denis Diderot, Paris 7 University, and AP-HP, Department of Hematology, Lariboisière Hospital, Paris, France;4. Denis Diderot, Paris 7 University, and AP-HP, Pathology Department, Lariboisière Hospital, Paris, France;5. Institut des Vaisseaux et du Sang, Lariboisière Hospital, Paris, France;6. INSERM U965, Angiogénèse et Recherche Translationnelle, Paris, France |
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Abstract: | IntroductionAlkalization of gastric fluids could inhibit plasmin-mediated and/or pepsin-mediated fibrinolysis. We evaluated the gastric antifibrinolytic effect of proton pump inhibitors in a live porcine model.Material and methodsSix pigs were randomly assigned to treatment with proton pump inhibitors vs no treatment. After endoscopic mucosal resection, 8 μm sections were incubated on fibrin films. Fibrinolytic activity was assessed through focal lysis time. One-hundred-and-forty-two mucosal sections and 129 submucosal sections were analysed. Twenty-four additional sections were analysed on plates containing tranexamic acid to explore pepsin-mediated fibrinolysis.ResultsFocal lysis times in treated vs control groups were 21.0 min vs 21.2 min (p = 0.39) in the mucosa, and 22.2 min vs 20.2 min (p = 0.56) in the submucosa. No lysis could be seen on the plasmin-inhibited fibrin plates.ConclusionOnly plasmin-mediated fibrinolysis was observed. Proton pump inhibitors had no significant plasmin-dependant antifibrinolytic effect. They may enhance haemostasis through different pathways. |
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Keywords: | PPI, proton pump inhibitor SD, standard deviation |
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