| 葡萄糖酸铜的毒性评价 |
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| 引用本文： | 吴坤,高志辉. 葡萄糖酸铜的毒性评价[J]. 黑龙江医药科学, 1992, 0(2) |
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| 作者姓名： | 吴坤 高志辉 |
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| 作者单位： | 哈尔滨医科大学公卫学院，哈尔滨医科大学公卫学院 |
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| 摘 要： | 通过葡萄糖酸铜的食品安全性评价表明,葡萄糖酸铜是中等急性毒性(LD_(50)为41mg/kg)和弱蓄积毒性的化学物质。在小鼠骨髓微核试验和小鼠精子畸变分析中,葡萄糖酸铜均显示阴性结果,并且在Ames试验中对鼠伤寒沙门氏菌株也无基因突变作用。
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| 关 键 词： | 葡萄糖酸铜 急性毒性 蓄积毒性 微核试验 精子畸变性 |
The evaluation of the toxicity of copper gluconate |
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| Wu Kun. The evaluation of the toxicity of copper gluconate[J]. Heilongjiang Medicine and Pharmacy, 1992, 0(2) |
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| Authors: | Wu Kun |
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| Abstract: | The food safety evaluation of copper gluconate showed that it is a chemical with median acute toxicity (the LD_(50) for mice was 419mg/kg), but without the accumulation of toxicity. The negative results were abtained in the micronucleus test of bone marrow and the sperm abnormality analysis in mice. Also, no genotoxicity in salmonella typhinurium strains was found in Ames test. |
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| Keywords: | copper gluconate acute toxicity accumulate toxicity micronucleus test sperm abnormality |
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