| 肝再生增强因子在肝脏中的作用 |
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| 引用本文： | 时红波[综述] 段钟平[审校]. 肝再生增强因子在肝脏中的作用[J]. 临床肝胆病杂志, 2013, 0(11): 878-880,I0001 |
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| 作者姓名： | 时红波[综述] 段钟平[审校] |
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| 作者单位： | 北京市肝病研究所,首都医科大学附属北京佑安医院,北京100069 |
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| 基金项目： | “十二五”国家科技重大专项资助课题（2012ZXl0002004-006;2012ZXl0004904-003-001）;国家自然科学基金（81300349）;北京市科技新星计划（xx2013016）;北京市肝病研究所基金（BJIH-01211） |
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| 摘 要： | 肝再生增强因子（ALR）除了促进肝再生,保护肝损伤之外,可能在肝脏的器官形成和发育中也发挥着重要作用。介绍了ALR在肝脏中的生物学功能和机制研究的最新进展,并归纳总结了ALR在肝脏疾病的诊断和治疗中的应用。指出ALR可能通过线粒体途径调控肝细胞的凋亡,从而参与肝脏的修复和再生。未来ALR可能作为肝衰竭患者肝再生及预后评估的候选分子,并有望成为临床治疗严重肝病和肝衰竭的有效药物。
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| 关 键 词： | 肝再生增强因子 肝再生 肝疾病 |
Research progress in role of augmenter of liver regeneration in the liver |
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| Affiliation: | Sill Hongbo , DUAN Zhongping. ( Beijing Institute of Hepatology, Beijing You＇an Hospital, Capital Medical University, Beijing 100069, China ) |
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| Abstract: | Recent studies have found that augmenter of liver regeneration （ALR） not only promotes liver regeneration and protects the liv from damage, but may also play an important role in the formation and development of the liver. The recent progress in research on the bi logical function and action mechanism of ALR in the liver is reviewed, and the application of ALR in the diagnosis and treatment of liver dt eases is summarized. It is suggested that ALR may regulate hepatocyte apoptosis through the mitochondrial pathway to promote liver repair and regeneration. In the future, ALR may be used as a candidate for evaluating liver regeneration and prognosis in patients with liver failure ALR holds promise as an effective medicine for treating severe liver disease and liver failure. |
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| Keywords: | augmenter of liver regeneration liver regeneration liver diseases |
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