非酒精性脂肪性肝病与脂肪细胞型脂肪酸结合蛋白的相关性

目的 通过测定患者血清脂肪细胞型脂肪酸结合蛋白（AFABP）水平,探讨血清AFABP与非酒精性脂肪性肝病（NAFLD）的相关性.方法 选取2010年7月至2010年11月于宁夏医科大学附属医院体检的人员160例.根据中华医学会非酒精性脂肪性肝病诊断标准将观察对象分为对照组（71例）和NAFLD组（89例）,分别比较两组间一般情况、身体质量指数（BMI）、血压、AFABP、血清胰岛素及血清学指标等各项病例资料.Spearman相关用于进一步分析血清AFABP与NAFLD及各代谢指标的相关性.计量资料组间比较采用t检验和秩和检验,计数资料组间比较采用χ2检验.结果 NAFLD组患者以男性为多,且与对照组比较,其存在更高的BMI、血糖、甘油三酯（TG）、ALT、AST及尿酸水平亦较高,而HDL水平较低;NAFLD组患者血清AFABP、胰岛素及胰岛素抵抗指数水平均高于对照组,差异有统计学意义;将AFABP与各参数进行Spearman相关分析研究显示,血清AFABP与NAFLD、BMI、胰岛素抵抗指数、血清胰岛素、血糖、TG、ALT、AST及尿酸水平呈正相关,而与HDL水平呈负相关;校正性别、年龄及BMI后,血清AFABP与NAFLD、胰岛素抵抗指数、血清胰岛素、血糖、TG、ALT及尿酸水平呈正相关,与HDL及AST水平无明显相关.结论 血清AFABP水平与NAFLD关系密切,其可能是NAFLD的独立血浆标志物,在NAFLD的发生发展中起了重要的作用.

Relationship between nonalcoholic fatty liver disease and adipocyte fatty acid-binding protein

Objective To investigate the relationship between nonalcoholic fatty liver disease （NAFLD） and serum level of adipocyte fatty acid - binding protein （AFABP）. Methods A total of 160 patients who underwent physical examination in the Affiliated Hospital of Ningxia Medical U- niversity from July to November 2010 were included in our study. These subjects were divided into two groups according to the diagnostic criteria for NAFLD formulated by the Chinese Medical Association： control group （n --71 ） and NAFLD group （n =89）. The two groups were compared with respect to general condition, body mass index （BMI）, blood pressure, AFABP, serum insulin, and other serological indices. The relationship of serum AFABP with NAFLD and other metabolic parameters was analyzed using the Spearman linear correlation coefficient. Comparison of measure- ment data was made by t test and rank sum test; comparison of enumeration data was made by chi - square test. Results There were more males than females in the NAFLD group. Compared with the control group, the NAFLD group had higher BMI and levels of blood glucose, triglyceride （TG）, aspartate aminotransferase （AST）, alanine aminotransferase （ALT）, and uric acid and lower high- density lipoprotein （HDL） level; in addition, the NAFLD group had significantly higher serum AFABP and insulin levels and homeostasis model assessment -estimated insulin resist- ance （ HOMA - IR）. The Spearman correlation analysis showed that serum AFABP was positively correlated with NAFLD, BMI, HOMA - IR, ser- um insulin, blood glucose, TG, ALT, AST, and uric acid but negatively correlated with HDL. After adjustment for sex, age, and BMI, serum AFABP was positively correlated with NAFLD, HOMA -IR, serum insulin, blood glucose, TG, ALT, and uric acid, but had no significant corre- lation with HDL and AST. Conclusion Serum AFABP is closely associated with NAFLD and may be an independent plasma marker of this dis- ease. AFABP plays a causative role in the pathogenesis of NAFLD.