基质金属蛋白酶-2和血管生成拟态在子宫内膜间质肉瘤中的表达探讨

目的探讨基质金属蛋白-2（matrix metalloproteinase-2，MMP-2）和血管生成拟态现象（vasculogenic mimicry．VM）在子宫内膜间质肿瘤中的表达。方法应用免疫组化Elivision法及双染法分别检测子宫内膜间质肉瘤39例、子宫内膜问质结节35例、正常子宫内膜40例中VM及MMP-2蛋白的表达情况。结果VM在子宫内膜间质肉瘤与正常子宫内膜、子宫内膜间质结节之间差别有显著统计学意义（P〈0.01）。MMP-2在子宫内膜间质肉瘤、正常子宫内膜、子宫内膜间质结节三者之间差别均有统计学意义（P〈0.05）。VM在子宫内膜间质肉瘤的核分裂计数中差异有统计学意义（P〈0.05）。子宫内膜间质肉瘤中VM和MMP-2蛋白的表达没有相关性（P〉0．05）。结论VM和MMP-2蛋白在子宫内膜间质肉瘤的发生发展中可能起到了一定的作用。

The expressions of matrix metalloproteinase-2 and phenomenon of vasculogenic mimicry in the endometrial stromal sarcoma

Objective To discuss the expression of MMP-2 protein and the vasculogenic mimicry（VM） in the endometrial stromal tumours （ESTs）. Methods Immunohistochemical elivision method and two tone method were used to detect VM and MMP-2 proteins in the 39 cases of endometrial stromal sarcoma and 35 cases of endometrial stromal nodule and 40 cases of normal endometrium. Results The expression rates of VM were significant difference in the endometrial stromal sarcoma and endometrial stromal nodule or normal endometrium respectively （P〈0.01）. The positive expression rates of MMP-2 were difference among the endometrial stromal sarcoma,endometrial stromal nodule and normal endometrium （P〈0.05）. The expression rates of VM in the en- dometrial stromal sarcoma were different between the difference of the number of caryokinesis（P〈0.05）. There was no corelation between the VM and expression of MMP-2 protein in the endometrial stromal sarcoma （P〉0.05）. Conclusion The VM and MMP-2 may play a role in the occurrence and development of endometrial stromal sarcoma.