| Becacizumab联合格栅样光凝治疗CRVO黄斑水肿的临床观察 |
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| 引用本文： | 王丽丽,李立婕,郑波,金丽英,张雯,霍敏,何斌. Becacizumab联合格栅样光凝治疗CRVO黄斑水肿的临床观察[J]. 国际眼科杂志, 2011, 11(10): 1769-1771. DOI: 10.3969/j.issn.1672-5123.2011.10.028 |
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| 作者姓名： | 王丽丽 李立婕 郑波 金丽英 张雯 霍敏 何斌 |
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| 作者单位： | 1. 中国陕西省西安市中心医院眼科,710003
2. 中国陕西省西安市第四医院眼科,710004 |
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| 基金项目： | 中国陕西省科技攻关基金资助项目 |
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| 摘 要： | 目的:评价贝伐单抗(Bevacizumab)联合格栅样光凝治疗视网膜中央静脉阻塞(central retinal vein occlusion,CRVO)黄斑水肿的临床疗效。方法:经纳入标准筛选后荧光素眼底血管造影(FFA)确诊CRVO引起黄斑水肿32例32眼。随机分为A和B两组,A组:玻璃体腔注射Bevacizumab(IVB)+格栅样光凝,B组:格栅样光凝。比较两组治疗后4,12,24wk最佳矫正视力、黄斑中心视网膜厚度(CMT)值、眼压,以及有无并发症发生情况。结果:A组疗效明显,视力提高快,视网膜厚度降低明显,在4,12,24wk观测黄斑区视网膜厚度分别为:351.81±57.68,320.44±58.94,296.50±52.15μm。视力及黄斑区厚度均与治疗前有显著性差异(P<0.05)。B组视力略有改善,但与治疗前无显著性差异(P>0.05),视网膜厚度降低,在4,12,24wk观测黄斑区视网膜厚度分别为:526.56±88.92,441.06±94.06,374.31±106.07μm。两组眼内压在治疗前后均无显著性差异(P>0.05)。A组应用激光的能量及点数均少于B组,减少治疗次数。结论:采用联合治疗方法能有效减轻黄斑水肿,提高视力,疗效持久。
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| 关 键 词： | 贝伐单抗 格栅样光凝 视网膜中央静脉阻塞 黄斑水肿 玻璃体腔注射 |
| 收稿时间： | 2011-07-05 |
Clinical observation of Becacizumab combined with grid photocoagulation for the treatment of cystoid macular edema associated with central retinal vein occlusion |
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| Li-Li Wang,Li-Jie Li,Bo Zheng,Li-Ying Jin,Wen Zhang,Min Huo and Bin He. Clinical observation of Becacizumab combined with grid photocoagulation for the treatment of cystoid macular edema associated with central retinal vein occlusion[J]. International Eye Science, 2011, 11(10): 1769-1771. DOI: 10.3969/j.issn.1672-5123.2011.10.028 |
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| Authors: | Li-Li Wang Li-Jie Li Bo Zheng Li-Ying Jin Wen Zhang Min Huo Bin He |
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| Affiliation: | Li-Li Wang1,Li-Jie Li1,Bo Zheng2,Li-Ying Jin1,Wen Zhang1,Min Huo1,Bin He1 1Department of Ophthalmology,Xi'an Central Hospital,Xi'an 710003,Shaanxi Province,China,2Department of Ophthalmology,Xi'an No.4 Hospital,Xi'an 710004 |
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| Abstract: | AIM:To evaluate the efficacy of intravitreaI Becacizumab (IVB)combined with grid photocoagulation for the treatment of cystoid macular edema(CME)associated with central retinaI vein occlusion(CRVO).METHODS:Tirty-two cases(32 eyes)of CME associated with CRVO made a definite diagnosis by FFA were divided into two groups randomly.IVB combined with grid photocoagulation group(A group):16 eyes.Grid photocoagulation group(B group):16 eyes.Best corrected visual acuity(BCVA),central macular thickness(CMT),intraocul... |
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| Keywords: | Becacizumab grid photocoagulation central retinal vein occlusion macular edema intravitreal injection |
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